methoxyflurane (ANALGESIC DRUG) Flashcards
What are the pharmacokinetics for methoxyflurane
administration: inhaled
distribution: plasma protein
metabolism: lung cells
excretion: exhalation
What are the pharmacodynamics for methoxyflurane
methoxyflurane is an inhaled analgesic designed to be self-administered using a handheld device
can be used as a non-opioid alternative to morphine/ with morphine for very severe pain
believed to reduce pain signals across gap junctions
possible side effects of methoxyflurane
dizziness
coughing
drowsiness
headache
nausea
hypotension
bradycardia
how is methoxyflurane presented on the road
in a bottle of 3ml (inhaler)
vial of methocyflurane 99.9% inhalation vapour, liquid
how is methoxyflurane administered
through a handheld inhaler
what are the indications for methoxyflurane
relief of moderate to severe pain with trauma and associated pain
what are the contraindications for methoxyflurane
pt under 18y/o
recent use of methoxyflurane ( over 15ml in the previous week)
known hypersensitivity to methoxyflurane/anesthetic gases
pt with liver damage/impairment
chronic kidney disease (stage 4 or 5)
altered LOC due to head injury, drugs or alcohol
cardiovascular instability (like heart faliure, hypotension or arrythmia)
reduced rr
history of severe adverse reaction to inhaled anaesthetic gas or malignant hyperthermia
How long does inhaled methoxyflurane last for
25-35 mins
what is the dosage of methoxyflurane
1 bottle of 3ml inhaled
maximum of 2 bottles (6ml) inhaled in 24 hours