Adrenaline 1:1000 (RESPIRATORY DRUG) Flashcards
what are the pharmacokinetics for adrenaline 1:1000
Administration: parental
Distribution: Plasma proteins
Metabolism: Liver
Excretion: urine
What are the pharmacodynamics for adrenaline 1:1000 (HINT- 4 different names)
catecholamine: agonises alpha and beta adrenoreceptors in cardiac, pulmonary and blood vessel tissue leading to tachycardia, bronchodilators and vasoconstriction
alpha-adrenoreceptor: increases peripheral resistance= increased myocardial and cerebral blood flow during cpr
beta-1 adrenoreceptor: increased contractility (positive inotrope) increased frequency of SA node depolarization (chronotrope), increased conduction through AV node (dromotrope)
beta-2 adrenoreceptor: causes smooth muscle relaxation, especially in lungs which causes subsequent bronchodilation, improves ventilation and aids oxygenation.
Its also a histamine antagonist
in simple terms what does adrenaline 1:1000 do to a pt
reverses allergic manifestations of acute anaphylaxis
relives the bronchospasms in acute severe asthma
how is adrenaline 1:1000 presented on the road
in a pre-filled syringe or ampuole which contains 1 milligram (mg) of adrenaline in 1 milliliters (ml) (1:1,000).
what are the indications of adrenaline 1:1000
anaphylaxis
life-threatening asthma WITH ailing ventilation and continued deterioration despite nebuliser therapy
what are the contra indications for adrenaline 1:1000
none
what are the cautions for adrenaline 1:1000
severe hypertension may occur in pt’s on non-cardioselective beta-blockers (like propranolol)
what is the route of administration for adrenaline 1:1000
IM ONLY
What is the initial dosage of adrenaline 1:1000 for adult pt
500 micrograms (mcg)
what is the max dose of adrenaline 1:1000
no limit
what are the adverse effects of adrenaline 1:1000
tachycardia
hypertension
