METHOTREXATE (ANTINEOPLASTC DOSES) Flashcards
What is the common indication for Methotrexate?
Answer: Methotrexate is commonly used to treat various types of cancer, including leukemia and lymphoma, as well as autoimmune conditions such as rheumatoid arthritis and psoriasis.
What is the normal maintenance dose for Methotrexate?
Answer: The normal maintenance dose for Methotrexate ranges from 7.5 to 25 mg per week, depending on the patient’s medical condition and response to treatment.
The dose of methotrexate used as an antineoplastic agent varies depending on the type of cancer being treated and the patient’s medical condition. It is typically given intravenously at higher doses than when used for autoimmune diseases. For example, the standard high-dose methotrexate regimen for treating osteosarcoma is 12 grams per square meter of body surface area over a 4-hour period, followed by leucovorin rescue therapy. The dosing and administration of methotrexate for cancer treatment should be done by a healthcare professional who is experienced in its use.
What is the drug class of Methotrexate?
Answer: Methotrexate belongs to the class of drugs known as antimetabolites.
What are the possible optimization issues when taking Methotrexate?
Answer: Possible optimization issues with Methotrexate include the risk of adverse effects such as nausea, vomiting, and liver damage. Dose adjustments may also be necessary based on individual patient factors such as age, weight, and kidney function.
What are the common side effects of Methotrexate?
Answer: Common side effects of Methotrexate include nausea, vomiting, and fatigue. It can also cause mouth sores, hair loss, and skin rash.
What should pharmacists lookout for when patients take Methotrexate?
Answer: Pharmacists should monitor patients for signs of adverse reactions such as liver damage and bone marrow suppression. They should also be aware of potential drug interactions and counsel patients on the importance of adhering to the dosing schedule. To minimize the risk of adverse effects, patients should be advised to take folic acid supplements to reduce the risk of mouth sores and gastrointestinal symptoms and to avoid alcohol and other medications that can interact with Methotrexate.
