Metabolic Syndrome

Question 1

Syndrome X and Insulin resistance is also known as

Answer 1

Metabolic Syndrome

Question 2

Risk Factors for Metabolic syndrome

Answer 2

Abdominal obesity (M=40, F=35)
Elevated BP (130/85)
Elevated Triglycerides ( >150)
Elevated FBG (>110)
Low HDL (Males<50)

Question 3

T/F: Patients with Metabolic syndrome are typically symptomatic before complications occur

Answer 3

False: Typically asymptomatic until they develop 1 or more complications (Ex: BP>130/85, Abdominal obesity)

Question 4

Diagnostic criteria for Metabolic Syndrome

Answer 4

If 3 risk factors are present

Abdominal obesity (M=40in, F=35in)
Elevated BP (130/85)
Elevated Triglycerides ( >150)
Elevated FBG (>110)
Low HDL

Question 5

Supporting lab tests for Metabolic Syndrome

Answer 5

Abnormal liver fxn
Increased CRP
Increased Uric acid
Microalbumin
Increased serum testosterone in women 

May be appropriate to order: Cardiac stress test, carotid US, Coronary Calcium scoring

Question 6

What are therapeutic life changes (TLC) for Met. Syndrome

Answer 6

Weight loss (Mediterranean Diet)
Dietary modifications
Increase aerobic exercise (30 min daily)

Question 7

Along with weight loss, balanced diet, and exercise, what other therapy should you give a patient with Metabolic Syndrome to prevent DMII?

Answer 7

Metformin

Question 8

MetS: Treatment for cardiac risk factors:

Answer 8

• HMG-CoA reductase inhibitors (Statin)
• Gemfibrozil
• Diet, exercise, weight loss

Question 9

Treatment for Obesity

Answer 9

Bariatric surgery

Orlistat, Sibutramine

Question 10

What has been associated with a 2 to 3 fold increase in risk for CHD/Stroke along with 2-fold increase risk of CV mortality?

Answer 10

Metabolic Syndrome