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Adult/Ped Medicine 5 > Innate Adaptive Immunity - Thiele > Flashcards

Innate Adaptive Immunity - Thiele Flashcards

1
Q

What is responsible for inflammation?

A

Inflamasome

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2
Q

Humoral adaptive or acquired immune system includes:

A

B Cells, plasma cells, antibody

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3
Q

Cellular adaptive or acquired immune system includes:

A

T cells, macrophages, neutrophils

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4
Q

80-90% of all immune responses occur through which branch of the immune system?

A

Innate

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5
Q

Histiocytes are macrophages in the:

A

Tissue

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6
Q

True/False: Mononuclear phagocytes have a role in both adaptive and innate immunity?

A

True

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7
Q

What is the predominant cell making up the white cell count?

A

Neutrophils

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8
Q

True/False: The host produces PAMPs.

A

False: host does not produce PAMPS so the innate system does not have to discriminate self from non-self.

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9
Q

What are PAMPs recognized by?

A

PRRs

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10
Q

PRRs on phagocytes results in: (4)

A

1) Phagocytosis
2) Opsonization through acute phase proteins
3) Elevated anti-microbial activity
4) Up-regulation of A) adhesion molecules, B) Co-stimulatory molecules

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11
Q

What is opsonization?

A

INDIRECT RECOGNITION through opsonins: Enhanced phagocytosis that is usually mediated by ligands and receptors, that utilizes the process of phagocytosis. THE JELLY ON THE BREAD

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12
Q

Eosinophils are important in:

A

Parasitic infections, allergies

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13
Q

Mast cells are important in:

A

allergies and anaphylaxis: Contain pre-formed histamine

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14
Q

Basophils during inflammation release potent _________ that exacerbate the response. The granules stain ______

A

Mediators, blue

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15
Q

_____________ have high nuclear to cytoplasmic ratios and include T-cells, B-cells, and NK cells

A

Lymphocytes

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16
Q

What cells react with tumor cells and virally infected cells and kill them through apoptosis and enzymes?

A

Natural Killer cells

17
Q

T/F: Acute phase proteins help in opsonization because cells have receptors for these acute phase proteins on their cell surface?

A

True

18
Q

What is the major coordinator of inflammation and made up of over 20 different proteins?

A

Complement (Part of Innate Immune system)

19
Q

A group of proteins that have an effect on other cells:

A

Interferons

20
Q

T/F: Alpha or beta interferons infect adjacent cells?

A

False: They stop infection of adjacent cells

21
Q

What interferon works through the adaptive immune response to activate T cells and macrophages?

A

Gamma interferon

22
Q

In acute inflammation you tend to have higher numbers of what cells?

A

Neutrophils and activated T helper cells

23
Q

In chronic inflammation you tend to have higher numbers of what cells?

A

Macrophages, t cytotoxic, and B cells

24
Q

A glycoprotein secreted by a plasma cell that is specific for an epitope on an antigen is what?

A

An antibody

25
Q

Fab is the fraction of _________ ___________ while Fc is fraction of _______________.

A

antigen binding, crystallization

26
Q

T/F: The TCR is secreted

A

False- never secreted

27
Q

T/F: T and B memory cells are produced following antigen stimulation?

A

True

28
Q

The biologically relevant portion of an antibody is what?

A

Fc (Fraction of crystallization)

29
Q

Antibodies functionality is conferred by: (4)

A

1) Fc receptors on cells
2) Complement activation
3) Complement receptors
4) Placental transfer

30
Q

T/F: IgM crosses the placenta

A

False

31
Q

T/F: IgM is a pentamer

A

TRUE

32
Q

T/F: IgM is first immunoglobulin secreted upon antigen stimulation

A

True

33
Q

T/F: IgE has an extra piece on the Fc portion that makes it bind only to mast cells

A

True- In the absence of antigen

34
Q

IgA is found in __________

A

Secretions

35
Q

Ig__ functions as a marker of maturation

A

IgD

36
Q

Genetic variability: ________ is conferred by the Fc portion. ____________ is minor genetic differences that are obtained from mom and dad. _______ is an antibody to the antigen combining site (the Vh and Vl)

A

Isotype, Allotype, Idiotype

37
Q

T/F: If IgM is present in the baby, the baby is responding?

A

True: If IgG is present, do not know if it is from mom or baby

Adult/Ped Medicine 5 (17 decks)

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