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Adult/Ped Medicine 5 > Immunology Practice Questions - Thiele > Flashcards

Immunology Practice Questions - Thiele Flashcards

1
Q
  1. Which of the following is a cell in the body that is capable of differentiating to a
    plasma cell and secreting antibody:
 A. B cells 
 B. Mast cells 
 C. Natural Killer cells 
 D. Neutrophils 
 E. Platelets
A

A. B cells

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2
Q
  1. The movement of cells from the blood to a site of inflammation due to the release of inflammatory mediators:
	A.	Chemotaxis 
	B.	Opsonization
	C.	Phagocytosis 
	D.	Pavementing
	E.	Pinocytosis
A

A. Chemotaxis

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3
Q
  1. Specificity and memory are the two major characteristics of:
	A.	The adaptive immune system
	B.	The complementary immune system 
	C.	The humorous immune system
	D.	The indirect immune system
	E.	The innate immune system
A

A. The adaptive immune system

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4
Q
  1. The immunoglobulin that is associated with allergic reactions:
	A.	IgA 
	B.	IgD 
	C.	IgE
	D.	IgG
	E.	IgM
A

C. IgE

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5
Q
  1. The part of an antigen that is recognized by an antibody or T cell receptor:
	A.	Agretype 
	B.	Allotype
	C.	Epitope
	D.	Idiotype
	E.	Isotype
A

C. Epitope

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6
Q
  1. Which of the following is true of an IgG molecule:A. It actively crosses the placenta
    B. It has a secretory component
    C. It has 5 antigen binding sites
    D. It is a B cell surface immunoglobulin receptor for antigen that is pentameric in structure
    E. It is the antibody produced on first exposure to antigen
A

A. It actively crosses the placenta

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7
Q
  1. The process by which cells non-specifically engulf material and enclose it within a vacuole in the cytoplasm is known as:
	A.	Chemotaxis
	B.	Cytolysis
	C.	Pavementing
	D.	Phagocytosis
	E.	Pragmatism
A

D. Phagocytosis

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8
Q
  1. The immunoglobulin that is found predominantly in secretions:
	A.	IgA 
	B.	IgD 
	C.	IgE 
	D.	IgG
	E.	IgM
A

A. IgA

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9
Q
  1. Which of the following cells plays a central role in the development of an immune response?A. Macrophages
    B. Neutrophil
    C. T-cytotoxic cell
    D. T-helper cell
A

D. T-helper cell

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10
Q
  1. General characteristics of the complement system includes proteins that are:A. Produced by the liver and circulate in the blood
    B. Produced only in response to antigenic stimulation
    C. Produced only in the spleen
    D. Specific for each antigen introduced to the immune system
A

A. Produced by the liver and circulate in the blood

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11
Q
  1. Which component is found in both the classical and alternative pathways and is central to complement activation?A. C1q
    B. C3
    C. C5a
    D. C9
A

B. C3

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12
Q
  1. The sum of the attractive and repulsive forces of all antibodies binding to an antigen is:A. Affinity
    B. Cross –reactivity
    C. Non-reactivity
    D Specificity
A

A. Affinity

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13
Q 
13.	Lysis of cells by complement is finalized by the formation of :
	A.	C1q
	B.	Immune Complexes
	C.	Membrane Attack Complex (MAC)
	D.	Properdin
A

C. Membrane Attack Complex (MAC)

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14
Q
  1. Which one of the following statements is TRUE concerning the secondary response to an antigen?
        A.	No memory cells are produced  B.	The predominant response is IgG. C.   	The quantity of IgM antibody produced is higher than in the primary 	esponse D.	The specificity of the antibody is different from the primary response.
A

B. The predominant response is IgG.

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15
Q
  1. Which of the following can be an antigen presenting cell through MHC Class II:
	A.	Bacterial 
	B.	Macrophage
	C.	Neutrophils 
	D.	Red blood cells
	E.	T-cells
A

B. Macrophage

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16
Q
  1. The cell in the body that has the potential to become a B-cell or T-cell is:A. Bone marrow fibroblasts
    B. Common lymphoid progenitor
    C. Common myeloid progenitor
    D. Fetal liver endothelial cells
A

B. Common lymphoid progenitor

17
Q
  1. T-cells receptors (TCR) and B-cell receptors (surface immunoglobulin) are similar as they:A. Acquire specificity through gene rearrangements
    B. Are heterodimers
    C. Have many receptors of only one antigenic specificity
    D. Have variable and constant regions
    E. All of the above
A

E. All of the above

18
Q
  1. The binding energy between an antigen and antibody:
A.	Is non-reversible
B.	Is reversible
C.	Is unrelated to the laws of mass action
D.	None of the above
A

B. Is reversible

19
Q
  1. The class or subclass of an immunoglobulin is determined by the:A. CH region
    B. CL region
    C. VH region
    D. VL region
A

A. CH region

20
Q
  1. Polymorphonuclear granulocytes include:A. B-cells
    B. Endothelial cells
    C. Neutrophils
    D. T-cells
A

C. Neutrophils

21
Q
  1. A T cell receptor recognizes processed antigen; whereas, a B cell receptor recognizes:
A.	8-12 amino acids.
B.	Conformational antigens (approximately 125 amino acids).
C.	Denatured antigen.
D.	Linear antigens.
A

B. Conformational antigens (approximately 125 amino acids).

22
Q
  1. Following antigen presentation by a B cell to a T helper cell, cytokines are produced and the B cell:A. Kills the T cell..
    B. Rearranges its VDJ and VJ genes.
    C. Secretes antibody
    D. Undergoes class switching, becomes a plasma cell and secretes an antibody
A

D. Undergoes class switching, becomes a plasma cell and secretes an antibody

23
Q
  1. Cells determine what peptides are to be presented to the immune system by:
A.    Chance contact 
B.    Phagocytosis by the T cell receptor
C.    Presentation through Class I or Class II molecules that have peptides bound to them
D.    Protein synthesis
E.    Secreting antibody
A

C. Presentation through Class I or Class II molecules that have peptides bound to them

24
Q
  1. Which one of the following is primarily part of the innate immune response?
	A.	B cells 
	B.	Cilia
	C.	T cells 
	D.	All of the above
	E.	None of the above
A

B. Cilia

25
Q
  1. The Fab region of the immunoglobulin molecule is important in:
A.	Activating complement following antibody binding to antigen 
B.	Binding of cells to an antibody that is bound to an antigen
C.	Binding to an antigen
D.	Determining the class or subclass of antibody
E.	Placental transfer
A

C. Binding to an antigen

26
Q
  1. Affinity maturation of the humoral immune response is due to:A. Continued stimulation of B cells by high levels of antigen
    B. DNA recombination by products of the D region genes
    C. Isotype switching
    D. Negative selection of T cells with the lowest helper potential
    E. Continued stimulation of B cells with low levels of antigen resulting in somatic mutation and the positive selection of B cells with the highest affinity for antigen
A

E. Continued stimulation of B cells with low levels of antigen resulting in somatic mutation and the positive selection of B cells with the highest affinity for antigen

27
Q
  1. Lymphocytes acquire their antigen specificity:A. As they enter the tissues from the circulation
    B. Before they encounter antigen
    C. Depending on which antigens are present
    D. From contact with self antigen
    E. In the secondary lymphoid organs
A

B. Before they encounter antigen

28
Q
  1. Phagocytosis:A. Can be enhanced by antigen binding to complement or antibody
    B. Is an antigen-specific process
    C. Must be preceded by antigen processing
    D. Rids the body of virus-infected cells
    E. Only occurs after plasma cells begin secreting antibody
A

A. Can be enhanced by antigen binding to complement or antibody

29
Q
  1. In bacterial infections, T cytotoxic cells do not seem to be very important. This is because:
A.	They are resistant to the enzymes that T cytotoxic cells release when 	
	activated
B.	Bacteria do not express MHC Class I that is necessary for cytotoxic T cell
 	recognition
C.	Bacteria do not express MHC Class II that is necessary for cytotoxic T cell 
	recognition
D.	Bacteria do not express MHC Class I that is necessary for T helper cell
	recognition
A

B. Bacteria do not express MHC Class I that is necessary for cytotoxic T cell
recognition

30
Q
  1. Antigens normally expressed only on embryonic cells but also sometimes found
    on tumor cells fixed in early development are known as:
		A.		Oncofetal antigens 
		B.  		HTLV-1 
		C.  		Maternal 
		D.  		Neonatal 
	E.  	Cryptic
A

A. Oncofetal antigens

31
Q
  1. In the treatment of leukemias, the process of bone marrow purging is performed
    by:A. Taking out the bone marrow and then just putting it back in
    B. Taking out the bone marrow, using antibody to the tumor to remove tumor cells and then putting the remaining cells back in
    C. Taking out the bone marrow, using antibody to the tumor to remove tumor cells and then putting the tumor cells back in
    D. Taking bone marrow from another cancer patient and putting it into the
    patient
A

B. Taking out the bone marrow, using antibody to the tumor to remove tumor cells and then putting the remaining cells back in

32
Q
  1. An example of a known oncogenic virus is:A. Herpes zoster
    B. HIV-2
    C. Epstein-Barr virus
    D. Vesicular stomatitis virus
A

C. Epstein-Barr virus

33
Q
  1. The normal immunological control of tumors is normally through which
    response:A, Humoral immunity
    B. Cell mediated immunity
    C. Innate immune system
    D. Immunological senescence
A

B. Cell mediated immunity

34
Q
  1. Extracellular bacteria are optimally killed by:
	A.	Macrophages 
	B.	Complement 
	C.	Antibody 
	D.	Macrophages plus complement 
	E.	Macrophages plus antibody plus complement
A

E. Macrophages plus antibody plus complement

35
Q
  1. Specific immunity to the intracellular organism M. tuberculosis in mice can be transferred to an uninfected mouse by:
	A	B-cells 
	B.	T-cells 
	C.	Macrophages 
	D.	Neutrophils 
	E.	IgG
A

B. T-cells

36
Q
  1. Cytotoxic T-cells:A. Are usually CD4+
    B. Recognize native viral antigen
    C. Kill virally infected cells
    D. Kill viruses directly
A

C. Kill virally infected cells

37
Q
  1. Protection against worm infestations is particularly associated with an increase in:
	A.	IgD 
	B.	IgE 
	C.	IgG 
	D.	IgA 
	E.	IgM
A

B. IgE

Adult/Ped Medicine 5 (17 decks)

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