Biological Functions of Immune Components

Question 1

An antibody to an Antigen is known as an immune what?

Answer 1

Complex

Question 2

With the classical complement pathway, you need what to activate it?

Answer 2

Antibody binds to antigen

Question 3

What activates C3 in the alternative pathway?

Answer 3

H2O

Question 4

C3 convertase in classical pathway? C3 convertase in alternative pathway?

Answer 4

Classical= C4b2a

Alt=C3bBb

Question 5

Ultimately, the complement pathway ends by doing what to the cell?

Answer 5

Lysis by MAC attack

Question 6

T/F: C5 activates adhesion molecules on macrophages?

Answer 6

True

Question 7

What cell controls other cells (macrophage, granulocyte, NK cell,etc. or in Thiele’s terms, is the “mother” of all cells?

Answer 7

T-Helper cells

Question 8

T-Cytotoxic cells are important in recognition and killing by what mechanism?

Answer 8

Granules: Lyse (perforin) and enzymes

Question 9

T helper cells: CD4 or CD8? Sees how many amino acids?

Answer 9

CD4+, CD4 binds MHC class II, looks for peptide in groove and sees 8-14 amino acids

Question 10

T cytotoxic cell: CD4 or CD8 and sees how many amino acids?

Answer 10

CD8+, CD8 binds MHC class I and looks for peptide in groove. Sees 8-14 amino acids. On all nucleated cells!!

Question 11

What are B cells?

Answer 11

Surface Immunoglobulin (sIg)= receptor for an epitope on an antigen. Also an antigen presenting cell. Sees 125 amino acids

Question 12

Linked recognition means what?

Answer 12

Process by which a TCR and a sIg recognize different epitopes on the same antigen, thus linking their response

Question 13

If you perform a transplant, you want to knock out what?

Answer 13

CD4