MET EOYS4 Flashcards

1
Q

what two important things does niacin (B3) create? [2] roles?

A
  • forms: NAD & NADP -> imporant hydrogen acceptors. when reduced forms: hydrogen donors
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2
Q

iron metabolism:

  • absorbed where in GI?
  • function in the body? (2)
  • stored where (2) and as what (1)?
A

iron metabolism:

  • absorbed where in GI: duodenum (and proximal jejunum)
  • function in the body: oxygen transport with Hb (1) myoglobin function in skeletal muscle
  • stored: liver (1) & macrophages (1) as ferratin (1)
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3
Q
A

tryptophan

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4
Q

describe the branches of the SMA (6)

A
  1. inferior pancreaticoduedenal artery
  2. jejnunal and ileal branches

3 middle colic artery

  1. right colic artery
  2. ileocolic artery -> appendicular artery
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5
Q

describe pathway of common hepatic artery –> hepatic artery proper —> ?? :)

A

common hepatic artery: branches into

  • gastroduodenal artery, which branches to give right gastroepiploic artery - which anastamoses with left gastroepiploic artery.
  • right gastric artery (goes to less curvature of stomach). anastamoes with left gastric artery

after these two: becomes the hepatic artery proper; branches into:

  • right hepatic artery –> cystic artery (gall bladder)
  • left hepatic artery
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6
Q

describe pathway of common hepatic artery –> hepatic artery proper —> ?? :)

A

common hepatic artery: branches into

  • gastroduodenal artery, which branches to give right gastroepiploic artery - which anastamoses with left gastroepiploic artery.
  • right gastric artery (goes to less curvature of stomach). anastamoes with left gastric artery

after these two: becomes the hepatic artery proper; branches into:

  • right hepatic artery –> cystic artery (gall bladder)
  • left hepatic artery
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7
Q
A

A: jenunal
B: superior mesentric
C ileocolic

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8
Q

what are the 3 branches of the IMA?

what connects the SMA & IMA?

A

inferior mesenteric artery branches:

  • left colic artery
  • sigmoidal artery
  • superior rectal artery
  • SMA & IMA connected by marginal artery
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9
Q

what are the 3 branches of the IMA?

what connects the SMA & IMA?

A

inferior mesenteric artery branches:

  • left colic artery
  • sigmoidal artery
  • superior rectal artery
  • SMA & IMA connected by marginal artery
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10
Q
A
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11
Q

which veins dont go to liver & directly drain into IVC? (4)

A
  • gonadal vein
  • renal vein
  • internal iliac vein
  • external iliac vein
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12
Q
A
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13
Q
A
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14
Q
A
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15
Q
A
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16
Q
A

A: left colic
B: sigmoidal
C: superior rectal

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17
Q

what is transamination?
how does it occur?
where does it occur mostly?
what is the enyzme used for it

A

transamination: transfer of an amino group. new amino acids can be made by using the carbon skeleton of other amino acids and transferreing a new side chain on it

mechanism:

  • keto acid / group (a.a but instead of the NH2, is replaced by C double bonded O) swaps with the amine of another amino acid
  • requires an intermediary: pyridoxal phosphate (from vitamin B6)

location: liver

Enzyme: tranaminase

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18
Q

what are glucogenic and ketogenic amino acids?

A
  • *glutogenic**: can be converted to glucose by gluconeogenesis or enter the TCA
  • can either be transaminated to oxaloacetate or pyruvate (or other intermediates that will form oxaloacetate):
  • e.g. alanine or glutamate

ketogenic: can be converted to ketone bodies, these can feed into the TCA cycle, mostly via A-CoA or acetoacetyl-CoA.

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19
Q

how is ammonia produced?

how is ammonia excreted from body ? why is it excreted?

A
  • occurs as a reult of amino acids underoing deamination reactions (reactions where you lose amine groups): when amino acids are converted to other molecules, but there arent other molecules to pick up with NH4+ (which is toxic).

- remove the NH4+ via the urea cycle:

20
Q

the conversion of the glutamine (a.a) to glutmate and then a-ketoglutarate generates WHAT?

why might this conversion occur?

why is lots of NH4+ produced?

A

generates free ammonia (as NH4+)

  • a-ketoglutarate is needed for TCA cycle for energy.
  • Glutamine has 2 amino groups, glutmate has 1, a-keto glutarate has 0 - so each step removes/adds an amino group so the metabolism of glutamine releases a lot of ammonium.
21
Q

what is glutamine used for? (4)

A

 Source of fuel during fasting - especially in muscles and immune cells.

 Used for gluconeogenesis, esp. in kidney.

 Produces ammonia, which can act as buffer for unwanted protons.

 Glutamine has anti-inflammatory properties in the gut.

Overall: fuel, building block, needed for metabolites: a-ketoglutarate and glutamate.

22
Q

MoA of urea cycle:

a) what is the rate determining step?
b) what are the two amino groups required? for it
c) what is the key regulating enzyme?

A

Rate controlling step:

o HCO3- + NH4+ –> carbamoyl phosphate (via enzyme carbamoyl phosphate synthase 1)
o Requires 2 ATP.
o Controlled allosterically by glutamate metabolite: N-acetyl glutamate - this is formed in an excess of glutamate, so drives urea cycle.

b) the two amino groups required from: aspartate (1) & ammonia (1)

essentially is a shuttle reaction of NH4 into from aspartate and ammonia into urea

23
Q

what does the addition of ApoC2 and ApoE by HDLs do to chylomicrons? [2]

A

- ApoC2 added: allows chylomicrons to give its triglycerides to peripheral cells

- ApoE added: allows chylomicron remenant to be taken up by the liver to deliver FA & cholesterol

24
Q

the lesser omentum connects what? [2]

A

liver and spleen

25
Q
A
26
Q

label the anatomy thats undergoing forgut developement at 10 weeks

A
27
Q
A

get a fusion of the dorsal mesogastrium & the transverse mescolon !

28
Q

& what are the two pink arrows pointing at?

A

- lesser omentum: liver and stomach

  • gastrosplenic ligament: stomach and spleen

top pink arrow: lesser sac
bottom pink arrow: epiploic foramen

29
Q

what is ascites?

A

ASCITES

fluid in the cavity. This is caused by liver cirrhosis which prevents the production of albumen and so fluid leaves the vasculature et

30
Q

what is the name of this muscle?
what is its role?
where does it recieve motor innervation from?

A

= stylopharnygeus muscle

  • function: elevates the pharnyx during swallowing
  • innervation: glossopharnygeal nerve
31
Q

label the mandible

  • which part serves as the muscle attachment point and moves the mandible?
A

- coronoid process: muscle attachment point

32
Q

what divdes the anterior and posterior portion of the tongue? [1]

what is found at the point of ^ V shape? [1]

A

what divdes the anterior and posterior portion of the tongue? [1]
sulcus terminalis

what is found at the point of ^ V shape? [1]
foramen cecum

33
Q

what are the 5 branches of the facial nerve? [5]

A

 Temporal  Zygomatic  Buccal  Mandibular  Cervical

Two Zulus Bit My Cat

34
Q

the mesentary connects which two structures? [2]

the greater omentum connects which two structures? [2]

A

small intestine to the posterior abdominal wall

stomach (greater curvature) to transverse colon !!

35
Q
A
36
Q

what thoracic level are of the following?

a) coeliac trunk
b) SMA
c) IMA
d) aortic bifurcation

A

what thoracic level are of the following?

  • *a) coeliac trunk: L12
    b) SMA: L1
    c) IMA: L3
    d) aortic bifurcation : L4**
37
Q

Three main branches of the coeliac trunk?

A

Left gastric

Splenic

Common hepatic

38
Q

which two arteries supply the lesser curvature of the stomach & what is their orgins? [2]

which two arteries supply the greater curvature of the stomach & what is their orgins? [2]

which artery supplies the fundus & origin?

A

which two arteries supply the lesser curvature of the stomach & what is their orgins? [2]
Right gastric (from common hepatic)
Left gastric (from coeliac trunk)

which two arteries supply the greater curvature of the stomach & what is their orgins? [2]
Right gastroepiploic (from gastroduodenal)
Left gastroepiploic (from splenic)

which artery supplies the fundus & origin?
short gastric arteries (from splenic)​

39
Q

what is this muscle?

A

cremaster muscle

40
Q

what are the layers of the spermatic cord? [3] where do each layer originate from [3]

A

superficial –> deep:

external spermatic fascia (from transveralis fascia)

cremaster muscle (from internal oblique)

external spermatic fascia (from external oblique)

41
Q

what is the difference betwenen a direct and indirect hernia? [2]

A

what is the difference betwenen a direct and indirect hernia? [2]

The difference is in the anatomical location:
Direct hernias protrude through the posterior (back) wall of the inguinal canal.
Indirect hernias protrude through the inguinal ring

42
Q

x

direct hernias pass directly through which structure? [1]

A

direct hernias pass directly through: hasslebachs triangle

43
Q
  1. how does the muscarlis externa / propria change in the oesphagus?
A
  • *top 1/3 made from skeletal muscle** = swallowing
  • *bottom 1/3 made from smooth muscle** = peristalsis
44
Q
A
45
Q

to make glucose, you need a source of energy and carbon units.

what are 3 sources of carbon that can be used in gluceoneogenesis?
what are 2 sources of energy that can be used in gluceoneogenesis?

A
  • *sources of carbon:**
  • lactate (from muscle - glycolysis). exported to liver can be made into pyruvate as a carbon source
  • amino acids - from muscle. (from proteolysis) sent to liver & can be made into pyruvate as a carbon source
  • glycerol (from lipolysis). sent to liver
  • *sources of energy:**
  • ATP (from glycolysis and Krebs cycle)
  • fatty acids (but cannot be used as C source !!)