Meilioidosis

Question 1

Organism for meiliodoisis?

Answer 1

Burkholderia pseudomallei

Question 2

Classic presentation of meilioidosis?

Answer 2

Farmers in Thailand
T2DM
CAP rapidly progressive
Gram -ve bacilli on gram stain

Question 3

Rx meilioidosis?

Answer 3

Ceftazidime
Co-trim to prevent relapse - long course

Meropenem in developed countries

Question 4

Transmission of meilioidosis?

Answer 4

Widely distributed in soil, surface water

Question 5

Classic clinical manifestations of meilioid?

Answer 5

CAP
sepsis - >50% are bacteraemic
skin lesions
GU tract - prostatic abscesses
Abscesses***
Bone and joint

Question 6

Epidemiology of meilioid

Answer 6

Warm places with lots of water
Bacteria lives in water and soil

Question 7

Transmission of meilioid?

Answer 7

Most acquisition percutaneous, also
respiratory and perhaps GI

Question 8

Risk factors for meilioidosis?

Answer 8

T2DM, alcohol use, chronic renal disease, chronic lung dis (anything that causes neutrophil defects)

Question 9

Differences of chronic meilioidosis?

Answer 9

CXR upper lobe changes, not bacteraemic

Question 10

What is the classical skin lesion appearance of meiliodosis?

Answer 10

Localised lesions, ulcer

Question 11

Diagnosis of meilioidosis?

Answer 11

Gram stain - pink (gram -ve)
Culture
Antigen detection assay