Bartonella Flashcards
What is bartonellosis?
Zoonotic Disease caused by Bartonella species
Gram negative bacilli
More than 30 species
Carrions disease - Bartonella Bacciliformis
Most important/common Bartonella Henselae (cat scratch disease)
How may bartonella present?
bacteremia, endocarditis or bacillary angiomatosis.
What is the diagnosis?
Bartonella
What causes cat scratch disease?
B.Henselae
- Bacillary angiomatosis
- Bacillary peliosis hepatis
- Bacteremia/Fever
- Endocarditis
- Necroinflammatory parenchymal nodules HIV dementia (?)
- Neuroretinitis (CSD)
How is B.Henselae transmitted?
Cat scratch or bite
Fleas from cat
How does cat scratch disease present?
It starts with a cutaneous lesion at the
inoculation site (primary lesion).
REGIONAL ADENOPATHY
Progresses - key features:
- Endocarditis
- Bacillary angiomatosis
- Bacillary peliosis hepatic - hepato and splenomegaly
Best diagnostic test for bartonella bacilliformis?
Gram stain - intra erythrocytic bacilliformis
Other manifestations of cat scratch disease?
CSD retinitis
CSD meningitis
Treatment of Cat Scratch Disease?
Azithromycin
Alternatives:
Clarithromycin, Cotrimoxazole, Rifampin,
Ciprofloxacin, Doxycycline
What causes Carrions disease?
Carrions disease - Bartonella Bacciliformis
Endemic in Peru at high altitude
What is the vector for Carrions disease?
Lutzomyia verrucarum - phlebotamine sand flies (same as leish)
Or L.peruvenis
Symptoms of Carrions disease?
Fever, jaundice, anaemia (key feature, develops quickly), malaise
Often get superimposed infections
Complications of Carrions disease?
Cardiac involvement - heart failure, pericardial eff, myocarditis, endocarditis.
Diagnosis of Carrions disease?
Gimsea stain
Culture takes weeks
Treatment of acute Carrions disease?
Ciprofloxacin
Which strain of bartonella affects homeless/alcoholics in USA and presents with fever, endocarditis and bacillary angiomatosis?
B.Quintana
Which bartonella strains cause Bacillary angiomatosis?
B.Henslae and B.Qunitana
Star shaped macular exudate - cause?
B.Henslae
Diagnosis of Bartonella Henslae?
Serology
Culture may take a while
Vector for Carrions disease, and species?
Lutzomyia fly
Bartonella Bacilliformis
Where do you find Carrions disease?
High altitude
Symptoms of Carrions disease?
Fever, abdo pain, HSM
Jaundice
ANAEMIA
What complications can occur in Carrions?
Cardiac - heart failure, endocarditis, myocarditis
What is the ∆?
Bartonella Bacilliformis
Intra erythrocytic on smear
