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Trop Med > Chagas > Flashcards

Chagas Flashcards

1
Q

What is the name of the vector for Chagas disease?

A

Triotomine fly
-Triotoma infestans
-Rhodinus
- Panstrongylus

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2
Q

How is chagas transmitted?

A

Fly bites
Deposits faeces
Trypomastigotes in blood of human
Enter cells and become emastigotes intracellularly

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3
Q

Where do you find epimastigotes?

A

Only in vector

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4
Q

How can chagas be transmitted?

A

Mother -> child
Blood transfusion
Vector

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5
Q

What investigations in acute phase of chagas?

A

Positive smear and culture (85%), PCR positive

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6
Q

What is Romana’s sign?

A

Unilateral periorbital swelling

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7
Q

What is this structure?

A

Promastigotes of T.Cruzi

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8
Q

What are the complications of chronic Chagas?

A

Mega bowel, mega oesophagus, cardiac complications, chagoma

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9
Q

Rx of acute chagas?

A

Benznidazole (60 days) or nifurtimox (90 days) - terrible side effects

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10
Q

What tests would you do for chronic trypanosomiasis?

A

PCR

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11
Q

Who do you treat for chronic chagas?

A

Children, congenital, <50 yrs old with no cardiomyopathy

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12
Q

What is the infective stage of Chagas?

A

Metacyclic Trypomastigote - found in vector

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13
Q

What is this?

A

Epimastigote

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14
Q

What are the hosts for trypanosome?

A

Small mammals

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15
Q

What is the Rx of trypanosomiasis and what are the SEs?

A

Benznidazole and nitrofurimox
GI upset
Peripheral neuropathy
Rash

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16
Q

What are the features of Romanas sign?

A

a) Unilateral lesion.
b) Unilateral palpebral edema
c) Unilateral conjunctivitis
d) Ipsilateral regional lymphadenopathy: preauricular lymph node.

17
Q

Other symptoms of acute chagas?

A

Unilateral nodule - chagoma (plus lymphadenopathy)
Persistent fever, fatigue
lymphadenopathy,
hepatosplenomegaly,
morbilliform rash, edema.

Acute myocarditis
Pericardial effusion
Meningoencephalitis

18
Q

Who gets symptoms of acute chagas?

A

Children, immunosuppressed
90% asymptomatic

19
Q

How is chagas transmitted?

A

Triatome fly, takes a blood meal
Defacates
Human/mammal scratches and faeces enters wound

Trop Med (49 decks)

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