Mehl. + UW TORCHeS - toxoplasma Flashcards
Mehl. Toxoplasmosis. HY triad in. neonate?
1) hydrocephalus, 2) chorioretinitis, and 3)
intracranial calcifications.
Mehl. Toxoplasmosis.
They don’t have to say the mom sat in a litter box with her cat during pregnancy.
.
Mehl. Toxoplasmosis. can be acquired from what food?
Can be acquired from pork consumption.
UW toxoplasma. Maternal risk factors?
Raw or undercooked meat
Unwashed produce (ie contaminated soil)
Handling of cat feces
UW toxoplasma. CP. Classic triad?
Chorioretinitis
Diffuse intracranial calcification
Hydrocephalus
UW toxoplasma. CP. nonspecific?
jaundice, hepatosplenomegaly, rash, growth restriction
UW toxoplasma. other neuro findings?
microcephaly (brain atrophy) or macrocephaly (severe hydrocephalus)
Seizures
UW toxoplasma. Dx?
Toxoplasma serology
or
PCR (of amniotic fluid)
UW toxoplasma. Tx?
Pyrimethamine, sulfadiazine, folinic acid
May decrease the risk of neurologic sequelae such as chorioretinitis, seizures, and intellectual disability
UW toxoplasma.
Although often asymptomatic, adults can have fever, lymphadenopathy, myalgias, and/or a diffuse, nonpruritic, maculopapular rash that resolves spontaneously.
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UW toxoplasma. transmission?
transplacental (vertical) transmission –> can result in devastating fetal infection
UW toxoplasma. mechanism on neuro tissue?
T gondii preferentially destroys fetal neural tissue, which results in ultrasound findings of bilateral ventriculomegaly (ie, hydrocephalus) and diffuse parenchymal intracranial calcifications, particularly within the basal ganglia
UW toxoplasma. additional findings (nonspecific) - kartojasi klausimas
ascites, hepatosplenomegaly, and fetal growth restriction (weight <10th percentile).
UW toxoplasma. what test should undergo to Dx?
Patients should undergo amniocentesis for T gondii PCR testing of amniotic fluid to confirm the diagnosis.
Uw. toxoplasma vs parvovirus 19?
Parvovirus B19 can cause mild illness with a diffuse rash in adults, and ascites due to fetal hydrops may occur.
However, other abnormal fluid collections (eg, pericardial/pleural effusion) are typical, and intracranial calcifications are not associated with this condition.
Uw. toxoplasma vs HSV?
Mothers typically have painful genital ulcers rather than a diffuse rash.
In addition, common ultrasound findings include calcifications of the placenta and umbilical cord, not the brain parenchyma.
Uw. toxoplasma vs VZV?
can cause growth restriction but typically presents with limb abnormalities (eg, bone/muscle hypoplasia). Although cortical atrophy can occur, intracranial calcifications are not seen.
