medchem 4

Question 1

true or false: nucleophiles are electron rich

Answer 1

true
they can have -ve charge ( stronger and more reactive )
or neural w/ lone pairs ( weaker )

Question 2

nucleophiles create bonds by

Answer 2

donating electrons towards the electrophile

Question 3

nucleophiles replaces — of the alkyl halide

Answer 3

replaces halogens since halogens are good leaving groups and have high electro-ve

Question 4

highest energy point from starting material to products in sn2 reaction is

Answer 4

transition state w/ square brackets indicating the structure CANT be isolated. dotted lines implies the bond is in the process of been made or broken

Question 5

nucleophile attacks from the — of the molecule

Answer 5

backside/ opposite to halogens

Question 6

the transition state consist of

Answer 6

nucelphile and substrate

Question 7

rate of reaction is depended on

Answer 7

concentration of nucleophile and substrate

Question 8

—- rises the energy of sn2 transition state

Answer 8

steric hindrance

Question 9

reactivity in SN2

Answer 9

primary > secondary and territory doesn’t react in SN2 mechanics

Question 10

good leaving groups — the energy of the transition state to — the SN2 reaction rate

Answer 10

lowers, increases

Question 11

SN2 leads to

Answer 11

inversion of chirality ( S becomes R and vice versa ), stechemistry is inverted as nucleophile will approach from direction 180 degrees away from the leaving halid