medchem 20

Question 1

amines have lone pairs which makes them —

Answer 1

basic and nucleophiles

Question 1

– have higher boiling point that alkanes due to the —- bonding

Answer 1

• amines
• intermolecular hydrogen bonding

Question 2

amines react as base if there’s a — and produce –

Answer 2

• acid proton
• amine salt

Question 3

arrange the basicity of the following
annaline
ammonia
cyclohexylamine
ch3nh2

Answer 3

ch3nh2 > cyclohexylamine > ammonia > aniline ( bc the lone pairs are not available in the aliphatic amines and they are in an aromatic sexts )

Question 4

electron — increases the basicity if amines as they push the electrons density towards the nitrogen and making it easier to accept a proton so its a better base

Answer 4

donating groups

Question 5

electron — groups decreases the basicity of the amines and pull the electrons density away from the N making it less easy to accept a proton and is a poor base

Answer 5

withdrawing groups

Question 6

reactions of amines w/ alkyl halids:
ammonia + ch3ch2-br –>
1 amine –>
2nd amine –>
3rd amine —>

Answer 6

primary amine (hydrobromide salt )
secondary amine (hydrobromide salt
teritary amine (hydrobromide salt )
quantatry amine ( ammonium bromide salt )

Question 7

reactions of amines w/ carbonyl groups produce

Answer 7

immine (schiff base + h20 )

Question 8

reduction of imime ( by h2 and metal catalyst ) leads to –

Answer 8

amine

Question 9

amines can be produced directly from —– by the formation of — and their — in a — step

Answer 9

• aldehyde , keton
• imine
• reduction ( reduction of mines by hydrogenation aka h2 or Ni aka a metal or by reducing agent )
• single

Question 10

amines cant be formed by —- under normal conditions bc they will produce —

Answer 10

• carbolyxic acid
• amine salts ( c.a + amines as a base —> amine salts )

Question 11

many amine drugs as —- which is a local anasethic and are — and are poorly soluble in —- which is why they are administered as —— to make them —-

Answer 11

• lidocaine
• lipophilic
• blood plasma
• hydrochloride salts
• water soluble
  ( only one will be protonated )
  so they are formulated as hydrochloride and not dihydrochloide due to the solubility and stability of hydrochlorides