Mechanism of target organ toxicity

Question 1

This can result to hypoxia that prevent transport of oxygen

Answer 1

Carbon monoxide

Question 2

This can result in decreasing circulation of leukocytes which damage the bone marrow cells

Answer 2

Chloramphenicol

Question 3

This can result to leukemia due to damage to bone marrow cells

Answer 3

Benzene

Question 4

This can cause arteriosclerosis due to this substance accumulation in arteries and veins

Answer 4

Cholesterol

Question 5

Comes into direct contact with the skin or is distributed internally

Answer 5

Dermal toxicity

Question 6

Dermal irritation from skin exposure to __

Answer 6

Gasoline

Question 7

Dermal corrosion from skin exposure to __

Answer 7

Sodium hydroxide

Question 8

Dermal itching, irritation, and sometimes painful rash from __ caused by __

Answer 8

poison ivy, urushiol

Question 9

Skin cancer due to ingesting __ or exposure to __

Answer 9

Arsenic, UV light

Question 10

Studies how external or environmental environment factors can switch genes on and off and change the programming of the cell

Answer 10

Epigenetic alterations

Question 11

It is the stable changes in the programming of gene expression, which can alter the phenotype without changing the DNA sequence

Answer 11

Epigenetics

Question 12

Part of the eye that has direct exposure to toxicants

Answer 12

Conjunctivitis and corneal erosion

Question 13

This can cause severe corneal corrosion

Answer 13

acids and strong akalis

Question 14

This may cause cataracts

Answer 14

Corticosteroids

Question 15

This may damage the optic nerves

Answer 15

Methanol (wood alcohol)

Question 16

Toxicity to the liver, bile duct, and gall bladder

Answer 16

Hepatoxicity

Question 17

Lipid accumulation in the hepatocytes

Answer 17

Steatosis

Question 18

Inflammation in the liver

Answer 18

Chemical hepatitis

Question 19

The death of hepatocytes

Answer 19

Hepatic necrosis

Question 20

Backup of bile salts into the liver cells

Answer 20

Intrahepatic cholestasis

Question 21

Cancer of the liver

Answer 21

Hepatic cancer

Question 22

Chronic fibrosis, often due to alcohol

Answer 22

Cirrhosis

Question 23

immune reaction resulting in hepatic necrosis

Answer 23

Hypersensitivity

Question 24

Toxicity of the immune system

Answer 24

Immunotoxicity

Question 25

Contact dermatitis due to exposure of

Answer 25

poison ivy

Question 26

Systemic lupus erythematosus in workers exposed to

Answer 26

hydrazine

Question 27

Immunosuppression by __
Leukemia induced by _

Answer 27

cocaine
benzene

Question 28

Toxicity in kidney

Answer 28

nephrotoxicity

Question 29

Represents toxicant damage to cells of the the CMS and peripheral nervous system

Answer 29

Neurotoxicity

Question 30

Neuron injury

Answer 30

Neuronopathies

Question 31

Axon injury

Answer 31

Axonopathies

Question 32

Toxicant damage to either male or female reproductive system

Answer 32

Reproductive toxicity

Question 33

Affects the upper respiratory system and the lower respiratory system

Answer 33

Respiratory toxicity