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Toxicology > Insecticides and pesticides > Flashcards

Insecticides and pesticides Flashcards

1
Q

Organophosphate other name

A

Parathion and Malathion

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2
Q

Organophosphate Moa

A

Binds to Acetylcholine, forming a stable phosphate -> ester bond -> inactivation of Ache -> Increased Ach (irreversible without treatment)

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3
Q

Organophosphate MOA signs and symptoms

A

DUMBELS

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4
Q

Organophosphate treatment

A

Atropine- inhibit Ach
Pralidoxime- aid for the treatment- enzyme deactivation
Endrophonium

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5
Q

Side effects of Organophosphate

A

delayed neurotoxicity (polyneuropathy, paralysis, axonal degeneration)

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6
Q

Not persistent toxicant

A

Carbamate

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7
Q

The clinical approach to management is similar to organophosphate poisoning

A

Carbamate

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8
Q

Carbamate moa

A

Reversible binding to Ach

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9
Q

Carbamate signs and symptoms and Treatment

A

DUMBELS
Atropine, Pralidoxime

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10
Q

Agents to kill mice and rats

A

Rodenticides

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11
Q

Rodenticides example

A

Coumarin derivative and heparin

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12
Q

Coumarin derivatives Moa

A

Inhibit gamma decarboxylation of Vitamin K-dependent factors

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13
Q

Coumarin derivative’s side effects

A

Hemorrhage/ excessive bleeding

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14
Q

Coumarin derivatives treatment

A

Vitamin K (Phytonadione); Fresh frozen plasma

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15
Q

Heparin Moa

A

Direct Thrombin inhibitor

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16
Q

Heparin signs and symptoms

A

Hemorrhage/ excessive bleeding

17
Q

Heparin treatment

A

Protamine sulfate

18
Q

DDT, Chlordane

A

Chlorinated HC pesticides

19
Q

Chlorinated HC pesticides are known to be

A

neurotoxin

20
Q

Chlorinated HC pesticides moa

A

inhibit the inactivation of the Na channel

21
Q

Chlorinated HC pesticides signs and symptoms

A

Seizure, Nausea and vomiting, Paresthesia, Respiratory depression, CNS stimulation (primary toxidrome)

22
Q

Botanical insecticides example

A

Nicotine, Rotenone, Pyrethrum

Toxicology (13 decks)

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