mechanism of action Flashcards
nalidixic acid
inhibition of bacterial DNA gyrase (cidal)
one metabolite is active
sulfonamides
inhibition of folate metabolism
trimethoprim
inhibition of DHFRase
2nd gen newer fq
inhibits dna gyrase (subunit A) in gram negative bacterias
and topoisomerase iv in gram positive bacterias
dna damaged
(dna gyrase- introduce negative supercoils - has A and B subunits - A nicks and seals while B introduce negative supercoils)
(topoisomerase - in gram positive - nicks and separate gram daughter DNA after replication)
erythromycin
active transportation of erythromycin
unionised at alkaline ph
erythromycin
inhibition of bacterial proteins synthesis - combines with ribosomal 50 s - interfere with translocation
vancomycin
bind to terminal d ala d ala sequence
inhibits its release from bactoprenol lipid carrier
vancomycin
bind to terminal d ala d ala sequence
inhibits its release from bactoprenol lipid carrier
protein synthesis inhibition
teracyclines, streptomycin, spectinomycin- 30s
50s - aminoglycoside, chloramphenicol, erythromycin, clindamycin
30-50s - aminoglycoside
linezolid
binds to 23 s (p site) - inhibition of initiation complex - overlaps 30 and 50 s sites - stops protein synthesis
no cross resistance
protein synthesis inhibition
SPECTINOMYCIN, quinupristine, dalfopristine, (PRISTINAMYCIN), MUPIROCIN, FUSIDIC ACID
mupirocin
inhibition of production of tRNA for isoleucine
nitrofurantoin
is reduced - damage dna
s, am, km, cm, eto, pto
inhibition if mycolic acid synthesis
cycloserine
interfere with bacterial cell wall synthesis by inhibiting enzyme that converts L alanine into d alanine (which is required for cell wall)
