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Pharmacology (personal) > adverse effects > Flashcards

adverse effects Flashcards

1
Q

sulfonamides

A 
N,V, epigastric pain
CRYSTALLURIA
Hypersensitivity
G6PD deficiency pts can have hemolysis
kernicterus in new born (displacement of bilirubin)
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2
Q

cotrimoxazole

A

n,v, pain, FOLATE DEFICIENCY (megaloblastic anemia) (teratogenicity- neonatal methemoglobinemia, hemolysis)

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3
Q

AIDS patient with jiroveci being treated by cotrimoxazole

A

fever, rash, bone marrow hypoplasia

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4
Q

Diuretics + cotrimoxazole

A

thrombocytopenia

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5
Q

nalidixic acid

A

gi upset, rashes, neurological (headache, drowsiness, vertigo, visual disturbances, seizures)
g6pd deficiency hemolysis
ci- infants

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6
Q

ciprofloxacin

A 
gi upset
cns - gaba antagonistic
hypersensitivity
tendinitis
pups- cartilage damage
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7
Q

lamofloxacin

A

qt prolongation, photosensitivity

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8
Q

sparfloxacin

A

qt prolongation, phototoxicity

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9
Q

gatifloxacin

A

qt prolongation, phytotoxicity etc

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10
Q

moxifloxacin

A

prolong qt qnd sometimes phototoxicity can occur

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11
Q

gemifloxacin

A

serum amino transferases, skin rash, warfarin effect enhance, qt prolongation

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12
Q

prulifloxacin

A

git, cns, photosensitivity, utricaria

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13
Q

erythromycin

A 
git discomfort
diarrheas
hearing impairment
hypersensitivity - rashes
estolate hypersensitivity - hepatitis with cholestatic jaundice (esp pregnancy)
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14
Q

erythromycin

A

inhibitor of cyp3a4 - terfenadine, astemizole, cispride toxicity - qt prolongation - arrhythmia and death

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15
Q

clarithromycin

A

same as erythromycin
also pseudomembranous colitis
rhabdomyolysis

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16
Q

pseudomembranous colitis

A

tetracycline
clarithromycin
clindamycin

17
Q

clindamycin

A

rash, urticaria, abd pain, pseudomembranous colitis (clostridium deficile super infection)
thrombophlebitis

18
Q

VANCOMYCIN

A 
RED MAN SYNDROME - rapid iv injection
stimulate mast cell - histamine release
skin allergy
BP fall
nerve deafness
kidney damage
19
Q

RED MAN SYNDROME

A

chills
fever
urticaria
flushing

VANCOMYCIN

20
Q

teicoplanin

A

rashes, fever, granulocytopenia, hearing loss

21
Q

linezolid

A 
mao inhibition
candidiasis
anemia
thrombocytopenia
rash
pruritus
git disturbances
optic NEUROPATHY
22
Q

nitrofurantoin in g6pd deficiency pts

A

hemolytic anemia

23
Q

brown urine

A

nitrofurantoin

24
Q

Frank’s psychosis

A

cycloserine

25
Q

fanconi anemia

A

tetracyclines outdated

26
Q

grey baby syndrome

A

chloramphenicol

Pharmacology (personal) (21 decks)

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