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Pharmacology (personal) > Drugs > Flashcards

Drugs Flashcards

1
Q

cyclosporine

A

binds to cyclophilin - calcineurin inhibition

tgf alpha - increased

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2
Q

tacrolimus

A

binds to fkbp - inhibits calcineurin

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3
Q

sacrolimus

A

macrolides antibiotic

binds to fkbp- inhibits mtor

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4
Q

Calcineurin

A

dephosphorylation of NFAT - intranuclear migration of nfat - gene transcription - t cel proliferation

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5
Q

azathioprine

A

cytotoxic immunosuppressants
purine antimetabolite
converted to 6-merceptopurine

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6
Q

liver transplantation

A

tacrolimus because it doesn’t require bile for absorption

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7
Q

methotrexate

A

folate antagonist

depress cytokine production and cmi

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8
Q

methotrexate

A

folate antagonist

depress cytokine production and cmi

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Pharmacology (personal) (21 decks)

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