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Spring 2020 - Physiology 1 > Mechanics of Respiration - Quiz 2 > Flashcards

Mechanics of Respiration - Quiz 2 Flashcards

1
Q

Goals of Respiration

A
  • Distribute air and blood flow for gas exchange
  • Provide oxygen to cells
  • Remove CO2
  • Maintain constant homeostasis for metabolic needs
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2
Q

Functions of Respiration

A
  1. Mechanics of Pulmonary Ventilation
  2. Diffusion of O2 and CO2 b/t alveoli and blood
  3. Transport O2 and CO2 to and from tissues
  4. Regulation of ventilation & respiration
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3
Q

External Respiration

A

Mechanics of breathing

Movement of gases in and out of body

Gas transfer from lungs to tissues of body

Maintain body & cellular homeostasis

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4
Q

Internal Respiration

A

Intracellular oxygen metabolism

Cellular transformation

Kreb cycle - aerobic ATP generation

Mitochondria and O2 utlization

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5
Q

What is primary purpose of Ventilation?

A

Maintain an optimal composition of alveolar gas

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6
Q

What acts as a stabilizing buffer compartment between the environment and pulmonary capillary blood?

A

Alveolar gas

  • O2 constanstly removed from alveolar gas by blood
  • CO2 continuously added to alveoli from blood
  • O2 replenished and CO2 removed by ventilation, by simple diffusion
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7
Q

What provides the stable alveolar environment?

A

The Two Phases of Ventilation

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8
Q

Weight of the Lungs

A

1.5% of Body Weight

1 kg in a 70 kg adult
60% of lung weight is Alveolar tissue

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9
Q

Alveoli have a very ________ surface area

A

Large

70 m2 internal surface area

40 times the external body surface area

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10
Q

Gas Diffusion Pathway

A

Short Pathway

Permits rapid and efficient gas exchange

1.5 µm b/t air and alveolar capillary RBC

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11
Q

What is the volume of blood in the Lung

A

500 mL

(10% of TBV)

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12
Q

Factors Needed to Alter Lung Volumes

A
  • Respiratory muscle generate force to inflate/deflate lungs
  • Tissue elastance and resistance impedes ventilation
  • Distribution of air movement in lung, resistance in airway
  • Overcoming alveolar surface tension
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13
Q

Breathing Cycle

A
  • Airflow needs pressure gradient
  • Air flows from higher to lower pressure
  • Inspiration: alveolar pressure < atmostpheric, allows airflow into lungs
  • Expiration: Alveolar pressure > atmospheric, allows airflow out of lung
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14
Q

Inspiration

A

Active Phase of Breathing

  • Motor signals from brainstem activate muscle contraction
  • Phrenic Nerve (C3, C4, C5) transmits motor stimulation to diaphragm
  • Intercostal Nerves (T1-T11) send signals to external intercostal muscles
  • Thoracic cavity expands to lower pleural space pressure
  • Pressure in alveloar ducts & alveoli decreases
  • Fresh air flows in until pressures are equalized
  • Inhaling is negative-pressure ventilation
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15
Q

Changes in alveolar pressure is generated by what?

A

Changes in pleural pressure

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16
Q

Most important muscle of Inspiration

A

Diaphragm

  • 75% of inspiratory effort
  • Thin, dome-shaped muscle on lower ribs, xiphoid process, lumbar vertebra
  • Innervated by Phrenic Nerve (C 3, 4, 5)
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17
Q

What happens during diaphragm contraction?

A
  • Abdominal contents forced downward and forward causing increase in vertical dimension of chest cavity
  • Rib margins lift and moved outward causing increase in transverse diameter or thorax
  • Diaphragm moves down 1 cm during normal inspiration
  • During fored inspiration, diphragm can move down 10 cm
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18
Q

Paradoxical Movement of Paralyzed Diaphragm

A

Upward movement with inspiratory drop of intrathoracic pressure

Occurs when diaphragm muscle is denervated

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19
Q

Transdiaphragmatic Pressure

A
  • Abdominal pressure effects entire diaphragm
  • Abdominal pressure is equal to atm. pressure in supine position when respiratory muscles are relaxed
  • Increasing abdominal pressure pushes diaphragm up into thoracic cavity, decreasing FRC

(Functional Residual Capacity)

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20
Q

What reduces Functional Residual Capacity (FRC)?

A

Intra-abdominal pressure

EX: Pregnancy, obesity, SBO, lap. surgery, ascites, abdominal mass, hepatomegaly, Trendelenburg, valsalva maneuver

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21
Q

How are External Intercostal Muscles (EIM) innervated?

A
  • 25% Inspiratory effort
  • Connects to adjacent ribs
  1. Motor neurons from respiratory brainstem go down spinal cord and leaves spinal cord via the intercostal nerves.
  2. Then they go to chest wall under each rib along with the intercostal veins and arteries.
  3. Contraction of EIM pulls ribs upward and forward
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22
Q

What happens when the External Intercostal Muscles (EIM) contract?

A
  • Thorax diameters increase in both lateral and anteroposterior directions
  • Ribs move outward in “bucket-handle” fashion
  • Intercostal nerves from spinal cord roots innervate EIMs
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23
Q

What happens if the External Intercostal Muscles (EIM) are paralyzed?

A

Not much. Paralysis of EIM does not really alter inspriations because the diaphragm is so effective, but sensation of inhalation decreases.

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24
Q

Accessory Muscles

A

Inspiration Muscle

Assist with forced inspiration during stress/excercise

  • Scalene Muscle
  • Sternocleidomastoid Muscle
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25
Q

Scalene Muscle

A

Accessory Muscle that attach cervical spine to apical rib

Elevate first two ribs during forced inspiration

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26
Q

Sternocleidomastoid Muscle

A

Accessory muscle that attach base of skull (mastoid process) to top of sternum and clavical medially

Raise the sternum during forced inspiration

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27
Q

Expiration

A

Passive Phase of Breathing

  • Chest muscle and diaphragm relax contraction
  • Elastic recoil of thorax and lungs return to equilibrium
  • Pleural and alveolar pressure rise
  • Gas flows passively out of lung
  • Active expiration during hyperventilation and exercise
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28
Q

What is needed for Active Expiration

A

Abdominal and Internal Intercostal Muscle Contraction

  • Rectus abdominus/abdominal oblique muscles
    • contraction raises intra-abdominal pressure to move diaphragm up
    • intra-thoracis pressure raises and forces air out lungs
  • Internal Intercostal Muscles
    • assist expiration by pullin ribs down and in
    • decrease thoracic volume
    • stiffen intercostal spaces to precent outward bulging
  • These muscles also contract forcefully during coughing, vomiting, and defecation
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29
Q

What is Transpulmonary Pressure?

A

Pressure difference between the alveolar pressure and pleural pressure on the outside of the lung

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30
Q

What do the alveoli tend to do when the pleural pressure tries to pull outward?

A

Collapse together

Even more profound in chlidren. PEEP is your best friend.

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31
Q

What is Recoil Pressure

A

Elastic forces that tend to collapse the lung during respiration

32
Q

What are the parts of the pleural membrane?

A

Visceral Pleura
Thin serosal membrane that covers the lobes of the lungs

Parietal Pleura
Lines the inner surface of chest wall, lateral mediastinum, and most of diaphragm

  • These two slide against each other and are hard to separate.
  • Separated by thin layer of serous fluid (a lot would be p. effusion)
    • EX: CHF, Cancer
33
Q

What do the visceral pleura and parietal pleura form when they fold inferiorly?

A

Pleura Sac

Both pleura lines this space enclosing a small amount of fluid

34
Q

What is Pleural Fluid?

A
  • Lubricant between the membranes, prevents frictional irriation
  • Makes visceral and parietal membrane stick together, maintains surface tension
  • Lymphatic drainage maintains constant suction on pleura (-5cmH2O)
35
Q

Pleural Pressure

A
  • Pressure of fluid in space between pleura membranes - always negative (-5cmH2O)
  • At rest, suction creates negative pressure at start of inspiration (-5cmH2O) - holds lungs open
  • Pressure get more negative during inspiration (-7.5 cmH2O) allowing for negative-pressure inspiration
  • Lung Collapse with Positive Pleural Pressure: Pneumothorax, Hemothorax, Chlythorax
36
Q

Tidal Volume (TV)

A

Volume of air moved in/out of lung during breathing

37
Q

Total Lung Capacity (TLC)

A

Volume in the lungs at max inflation

TLC = IRV + ERV + RV + TV

TLC = 5.5 L

38
Q

Inspiratory Reserve Volume (IRV)

A

Max volume that can be inhaled from the end-inspiratory level

IRV = 2.5 L

39
Q

Expiratory Reserve Volume (ERV)

A

Max volume of air that can be exhaled from end-expiratory position

ERV = 1.5 L

40
Q

Residual Volume (RV)

A

Volume of air remaining in lungs after maximal exhalation

RV = 1 L

41
Q

Vital Capacity (VC)

A

Volume breathed out after deepest inhalation

VC = IRV + TV + ERV

VC = 4.5L

42
Q

Functional Residual Capacity (FRC)

A

Volume in lungs at end-expiratory position

FRC = ERV + RV

FRC = 2.5 L

43
Q

Spirometry

A
  • 4 Volumes - Based on Ideal Body Weight
    • IRV = 2.5 L
    • ERV = 1.5 L
    • RV = 1 L
    • TV = 0.5 L
  • 4 Capacities
    • VC = 4.5 L
    • IC = 3 L
    • FRC = 2.5 L
    • TLC = 5.5 L
  • Effort Dependent
  • Values vary to height, age, sex & physical training
44
Q

Lung Capacities

A

A capacity is always a sum of certain lung volumes

TLC = IRV + TV + ERV + RV

VC = IRV = TV + ERV

FRC = ERV + RV

IC = TV + IRV

45
Q

Lung Compliance

A
  • Measure of distensibility of lungs
  • Compliance = Change in Lung Volume / Change in Lung Pressure
    • Cpulm = ΔVpulm / ΔPpulm
46
Q

What is the extent of lung expansion dependent on?

A

Increase of transpulmonary pressure

47
Q

Normal static lung compliance

A

70 - 100 mL of air / cm H2O transpulmonary pressure

48
Q

Different compliances for inspiration and expiration based on the _________ of lungs

A

Elastic forces

49
Q

What REDUCES lung compliance

A

Higher or Lower Lung Volumes

Higher expansion pressures

Venous Congestion

Alveolar Edema

Atelectasis and FIbrosis

50
Q

What INCREASES lung compliance

A

Increased Age

Emphysema secondary to alterations of elastic fibers

51
Q

Pressure-Volume Curve: Hysteresis

A
  • Inflation and deflation curves differ
  • Lung volume during deflation is larger than during inflation
  • Trapped gas in closed small airways cause higher lung volumes
  • Increased age and lung disease have more small airway closure
52
Q

What are elastic lung tissue made of and its natural state

A

Elastin and Collagen fibers of the lung - natrual state is contracted coils

53
Q

How is elastic force generated?

A

Return of coiled state after being stretched and elongated

Recoil force helps deflate lungs

54
Q

Surface Air-Fluid Interface

A

2/3 of Total elastic force in lung

Surface tension of H2O

55
Q

What holds alveoli open?

A

Complex syngery between air and fluid

Surfactant reduces surface tension and keep alveoli from collapse

56
Q

DPPC - Dipalmitoyl Phosphatidyl Choline

A

Main constituent of surfactant

Hydrophobic and Hydrophilic ends

Opposes water self-attraction and reduces surface tension

Alignment of Repulsive Forces

Reduction of surface tension greater when film compressed closer as DPPC repel each other more

57
Q

Functions of Surfactant

A
  • Lowers surface tension of alveoli and lung
    • increase compliance, decrease work of breathing
  • Promotes stability of alveoli - prevent collapse and helps parenchyma
    • 300 million tiny alveoli tend to collapse
  • Prevents drawing of fluid into alveoli from capillaries
58
Q

Total Ventilation/ Minute Ventilation

A

Total volume of air into lungs per minute

Minute ventilation = Tidal Volume x Frequency

Average 6L/min = 500 cc x 12 breaths/min

59
Q

Alveolar Ventilation

A

70% of minute ventilation due to (30% dead space)

Alveolar O2 concentration is steady when supply = demand

VT = VA + VD

60
Q

Wasted Ventilation

A
  • Anatomical dead space and any portion of alveoli that does not exchange gas
  • Physiologic Dead Sace - deviation from ideal ventilation related to blood flow
  • Ventilation/blood flow (V/Q) mismatch when blood flow is blocked - emboli
61
Q

Airway Closure

A
  • Base of lung has gas trapped and cant breathe out CO2 with every breath
    • defective gas exchange in dependent (down) regions (intermittently ventilated)
  • Closing Volume (volume of closed small airways)
    • CV > FRC leads to atelectases and hypoxemia
  • In patients with chronic lung disease
62
Q

Bernoulli Effect

A

As speed of fluid increases, pressure exerted by fluid decreaases

63
Q

Airflow through Tubes

A

Low flow rates = laminar/constant/parallel streams

High flow rates = turbulence

(Airway branches/diameter, velocity/direction changes)

64
Q

Flow velocity in a tube in Laminar Flow

A

Velocity in center of tube/airway is twice as fast than at the edges

65
Q

Poiseuille Law

A

Describes resistance to flow through a tube

  • Pressure increases proportional to flow rate & gas viscocity
  • Small airway radius and longer distances increase flow resistance
  • R = (8 x L x n) / (π x r4) *R: resistance, L: length, n: viscosity, r: radius
  • Reducing r by 16% will double R
  • Reducing r by 50% will increase R by 16x
66
Q

Ohm’s Law

A

P = F x R

*P: Pressure, F: FLow, R: resistance*

67
Q

What happens during turbulent flow?

A
  • Local eddies form at sides of airway and flow gets disorganized
  • Pressure no longer proportional to flow
  • More density, velocity, and airway resistance = more turbulence
68
Q

Chief Site of Airway Resistance

A

Major resistance at medium-sized bronchi

  • Most of pressure drops at seventh division
  • Very small bronchioles have very little resistance
    • < 20% drop at airways < 2mm
    • Parardox due to large number of small airways
    • Air speed gets low, difffusion takes over
69
Q

Factors of Airway Resistance

A
  • Lung Volume - as lung vol. reduced, resistance increases
  • Bronchial Smooth Muscle
    • Airway contraction = increased resistance
  • Density and Viscosity of Inspired Gas
    • Density has greater effect on resistance

Less space = more resistance

70
Q

Work of Breathing

A
  • Work = Pressure X Volume (W = PxV)
  • Oxygen consumption used to determine work of breathing
71
Q

What is the O2 cost of breathing?

A

5% of total resting oxygen consumption

30% for hyperventilation

High cost in COPD limits exercise ability

72
Q

What position decreases abdominal pressure and allow for easier lung ventilation?

A

Upright, Reverse Trendelendburg, & Prone

73
Q

What can FRC and TLC be determined by?

A
  1. Helium dilution
  2. Nitrogen washout
  3. Body plethysmography
74
Q

What CANT Spirometry measure?

A

CANT measure Residual Volume, meaning FRC and TLC cant be determined using spirometry alone

75
Q

What happens to TLC, RV, and PEFR in Obstructive Lung Disease?

A

TLC: Increases

RV: Increases

PEFR: Decreases

Coving of Expiratory Curve

76
Q

What happens TLC, RV, and PEFR in Restrictive Lung Disease?

A

Restrictive - shifts to the Right

TLC: Decreases

RV: Decreases

PEFR: Decreases

Decreased Inspiratory Flow

No Coving

77
Q

What happens to TLC, RV, PEFR in Fixed Upper Airway Obstruction (Tracheal Stenosis, Tumor, Goiter)

A

RV: Increased

PEFR/PIFR: Decreased

Spring 2020 - Physiology 1 (24 decks)

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