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Step 2 CK > May 5th > Flashcards

May 5th Flashcards

1
Q

What is leukocyte adhesion deficiency

A

Defective integrins on the leukocyte surface, neutrophils are thus unable to migrate

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2
Q

What are the s/sx of leukocyte adhesion def?

A

DELAYED UMBILICAL CORD SEPARATION; Recurrent skin and mucosal infections (cellulitis, abscess, periodontal), poor wound healing, lack of purulence, bx devoid of neutrophils; marked leukocytosis and neutrophilia

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3
Q

What is Wallenberg syndrome?

A

Lateral medullary syndrome; associated with vertebral artery dissection, see vertigo, ipsilateral ataxia)

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4
Q

What is the genetic defect in Prader-Willi syndrome?

A

Deletion of paternal 15q11-q13

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5
Q

What is the genetic defect in Angelman syndrome?

A

Deletion of maternal 15q11-q13

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6
Q

How is sustained monomorphic vtach managed?

A

HDS - IV amiodarone; extremely symptomatic/not HDS - synchronized cardioversion

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7
Q

How is Ventricular fibrillation or pulseless Vtach managed?

A

Immediate defibrillation

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8
Q

What is the MOA of oxybutinin in urge incontinence?

A

Antimuscarinic - results in increased bladder capacity and decrease detrusor contractions by reducing Ach activity

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9
Q

What is the use of duloxetine in incontience?

A

Can be used for stress incontinence in patients with unipolar depression

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10
Q

What is the MOA of bethanechol?

A

Cholinergic agonist - used in urinary retention due to neurogenic bladder

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11
Q

What is the inheritance pattern of G6PD def?

A

X linked

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12
Q

What are the predominating organisms in wounds following severe burns?

A

Immediate: gram positive; after more than 5 days - GNRs and fungi

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13
Q

What is treatment for eczema herpeticum?

A

Systemic acyclovir

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14
Q

What medications can cause tardive dyskinesia?

A

Antipsychotics and metoclopramide

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15
Q

What is the treatment for tardive dyskinesia?

A

Stop offending agent if possible; switch to second gen antipsychotic (quetiapine, clozapine); treat with valbenazine (inhibitor of vesicular monoamine transporter 2)

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16
Q

What is the treatment for borderline PD?

A

DBT - primary treatment

17
Q

What are the treatment options for rosacea?

A

Topical metronidazole for papulopustular type; laser or brimonidine for erythematotelangiectatic type

18
Q

What are the risk factors for C diff?

A

Recent antibiotic, hospitalizations, and PPI use

19
Q

How does alcohol-related heart disease typically manifest?

A

Dilated cardiomyopathy with impaired LV systolic function

20
Q

How does cardiac involvement of amyloid typically manifest?

A

Leads to restrictive cardiomyopathy - right-sided HF, diastolic dysfunction

21
Q

What is the most common form of glomerulopathy associated with HIV?

A

FSGS

22
Q

What is a common cardiac finding in ankylosing spondylitis?

A

Aortic regurg - early diastolic murmur

Step 2 CK (19 decks)

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