May 5th Flashcards
What is leukocyte adhesion deficiency
Defective integrins on the leukocyte surface, neutrophils are thus unable to migrate
What are the s/sx of leukocyte adhesion def?
DELAYED UMBILICAL CORD SEPARATION; Recurrent skin and mucosal infections (cellulitis, abscess, periodontal), poor wound healing, lack of purulence, bx devoid of neutrophils; marked leukocytosis and neutrophilia
What is Wallenberg syndrome?
Lateral medullary syndrome; associated with vertebral artery dissection, see vertigo, ipsilateral ataxia)
What is the genetic defect in Prader-Willi syndrome?
Deletion of paternal 15q11-q13
What is the genetic defect in Angelman syndrome?
Deletion of maternal 15q11-q13
How is sustained monomorphic vtach managed?
HDS - IV amiodarone; extremely symptomatic/not HDS - synchronized cardioversion
How is Ventricular fibrillation or pulseless Vtach managed?
Immediate defibrillation
What is the MOA of oxybutinin in urge incontinence?
Antimuscarinic - results in increased bladder capacity and decrease detrusor contractions by reducing Ach activity
What is the use of duloxetine in incontience?
Can be used for stress incontinence in patients with unipolar depression
What is the MOA of bethanechol?
Cholinergic agonist - used in urinary retention due to neurogenic bladder
What is the inheritance pattern of G6PD def?
X linked
What are the predominating organisms in wounds following severe burns?
Immediate: gram positive; after more than 5 days - GNRs and fungi
What is treatment for eczema herpeticum?
Systemic acyclovir
What medications can cause tardive dyskinesia?
Antipsychotics and metoclopramide
What is the treatment for tardive dyskinesia?
Stop offending agent if possible; switch to second gen antipsychotic (quetiapine, clozapine); treat with valbenazine (inhibitor of vesicular monoamine transporter 2)
What is the treatment for borderline PD?
DBT - primary treatment
What are the treatment options for rosacea?
Topical metronidazole for papulopustular type; laser or brimonidine for erythematotelangiectatic type
What are the risk factors for C diff?
Recent antibiotic, hospitalizations, and PPI use
How does alcohol-related heart disease typically manifest?
Dilated cardiomyopathy with impaired LV systolic function
How does cardiac involvement of amyloid typically manifest?
Leads to restrictive cardiomyopathy - right-sided HF, diastolic dysfunction
What is the most common form of glomerulopathy associated with HIV?
FSGS
What is a common cardiac finding in ankylosing spondylitis?
Aortic regurg - early diastolic murmur
