May 4th Flashcards
What is wiskott-aldrich syndrome?
X linked recessive defect in WAS protein; results in impaired cytoskeleton changes in leukocytes and platelets
What are the clinical features of Wiskott-Aldrich syndrome?
Eczema, microthrombocytopenia, and recurrent infections
What is the cause of bacillary angiomatosis?
Bartonella - gram neg bacillus
What is the immunization schedule for varicella?
2 doses of VZV vaccine ages 1 and 4
What does an intention to treat analysis help with?
Selection bias
Crystals in pseudogout have what birefringent pattern?
Positive
What is the treatment for diffuse esophageal spasm?
CCB (eg diltiazem)
What is the MOA of sodium bicarbonate in TCA overdose?
Used when QRS interval > 100 msec; increases extracellular pH, resulting in drugs decreased avidity for sodium channels; affects ability of TCAs to bind to fast sodium channels
What is seen on autopsy in Lewy Body dementia?
“Lewy bodies” or eosinophilic intracytoplasmic inclusions; accumulations of alpha synuclein protein, may be seen in the substantia nigra, locus ceruleus, dorsal raphe and substantia innominata
Lewy body dementia has increased deposits of what?
Alpha synuclein protein
What are the characteristics of dementia with lewy bodies?
Alterations in conciousness, fluctuations in cognition, visual hallucinations, parkinsonism;
How are DLB and Parkinson disease different?
Dementia occurs late in the course of Parkinson disease
What cancers produce PTHrp?
Squamous cell, renal, bladder, breast and ovarian
What are the signs/symptoms of mixed cryoglobulinemia?
Palpable purpura, proteinuria, hematuria, arthralgias, HSM, hypocomplementemia; clue - underlying HCV infection
How is beta blocker OD treated?
1st IV fluids and IV atropine; if refractory give IV glucagon - glucagon increases intracellular cAMP
