Malignant Breast Pathology Flashcards
When do angiosarcomas arise?
post radiotherapy
Where do breast mets travel from?
bronchial carcinoma ovarian serous carcinoma clear cell carcinoma of the kidney malignant melanoma leiomysarcoma
Where do breast carcinomas arise from?
glandular epithelium of the terminal duct lobular unit (TDLU)
What are ductal pre cursor lesions?
epithelial hyperplasia
columnar cell change +/- atypia
atypical ductal hyperplasia
ductal carcinoma in situ
What are lobular pre cursor lesions?
lobular in situ neoplasia
What is an in situ carcinoma?
confined within the basement membrane of acini and ducts
cytologically malignant but non invasive
What does <50% of the lobule involved indicate?
atypical lobular hyperplasia
What does >50% of the lobule involved indicate?
lobular carcinoma in situ
What are the characteristics of lobular in situ neoplasia?
incidence decreases after menopause
may calcify + appear on mammograms
often many
usually incidental finding
What is the pathology of lobular in situ neoplasia?
ER positive
E-cadharin negative (due to CDH1 gene mutation)
How are lobular in situ neoplasia diagnosed and managed?
vacuum biopsy
What is the only type of breast cancer that can be “cured”?
ductal carcinoma in situ
What % of breast malignancies are ductal carcinoma in situ, if caught early?
15-20%
How does DCIS present?
unicentric
may involve the skin of the nipple - Pagets
What is Pagets disease of the nipple?
high grade DCIS extending along the ducts to reach the epidermis of the nipple - to cause a superficial erosion
