Male Repro

Question 1

Testosterone production

Answer 1

95% leydig, 5% adrenals

Question 2

Dihydrotestosterone

Answer 2

Potent androgen created from testosterone by 5 alpha reductase. responsible for prostate development

Question 3

Methyl testosterone

Answer 3

Testosterone analog, orally effective used for testosterone hormone replacement.

Question 4

Oxandrolone

Answer 4

dihydrotestosterone derivative, orally active, cannot be converted by aromatase into estrogens, promotes muscle growth (anabolic steroid)

Question 5

Androgen therapy AE

Answer 5

epiphyseal plate closure, due to conversion to estrogens at growth plates. priapism, hepatic carcinoma, hypogonadism, aggression, urinary obstruction, baldness, gynecomastia, shrunken testes, abnormal hair growth

Question 6

Cyproterone acetate

Answer 6

androgen antagonist used to reduce sexual drive in men and treat hirsuitism in women.

Question 7

Flutamide

Answer 7

Androgen antagonist. Nonsteroidal pure receptor antagonist used in advanced prostate cancer, AE: gynecomastia and hepatotoxicity

Question 8

Bicalutamide

Answer 8

Androgen antagonist. Nonsteroidal pure receptor antagonist used in advanced prostate cancer, AE: gynecomastia and hepatotoxicity

Question 9

Nilutamide

Answer 9

Androgen antagonist. Nonsteroidal pure receptor antagonist used in advanced prostate cancer, AE: gynecomastia and hepatotoxicity

Question 10

Spironolactone

Answer 10

Weak antagonist of testosterone, can be used for Hirsuitism, acne in women

Question 11

Gonadorelin

Answer 11

Acetate salt of human recombinant GnRH. Binds GnRH receptors and stimulates the release of gonadotropins. Improves male fertility with pulsitile.

FSH and LH for therapeutic purposes. single or pulsatile use is stimulatory, continuousshuts down the HPG axis..

Question 12

Leuprolide

Answer 12

Synthetic GnRH Agonist, used for castration for cancer. Continuous administration leads to desensitization. pulsitile admin. induces FSH, LH release for ovarian stimulation

Question 13

Degarelix

Answer 13

GnRH antagonist, treats benign prostate hyperplasia.

Question 14

Finasteride

Answer 14

5 alpha reductase inhibitor, prevents conversion of T to DHT. used for BPH, male pattern baldness.

Question 15

Dutasteride

Answer 15

5 alpha reductase inhibitor, prevents conversion of T to DHT,. Used for BPH, male pattern baldness, hirsutism in women.

Question 16

Sildenafil

Answer 16

Phosphodiesterase 5 inhibitor, prevents the degredation of cGMP, orally effective,
AE: headache, flushing, dyspespsia, nasal congestion

Question 17

Vardeafil

Answer 17

Phosphodiesterase 5 inhibitor, prevents the degredation of cGMP, orally effective,
AE: headache, flushing, dyspespsia, nasal congestion

Question 18

Tadalafil

Answer 18

Phosphodiesterase 5 inhibitor, prevents the degredation of cGMP, orally effective,
AE: headache, flushing, dyspespsia, nasal congestion