HRM Antineoplastics

Question 1

Goserelin

Answer 1

GnRH analogue causes initial jump in FSH, LH, flare in cancer growth. Long term causes decreased receptors in pituitary and decreased hormones.

Question 2

Leuprolide

Answer 2

GnRH analogue causes initial jump in FSH, LH, flare in cancer growth. Long term causes decreased receptors in pituitary and decreased hormones.

Question 3

Aminoglutethimide

Answer 3

nonsteroidal competitive aromatase inhibitor. prevents formation of estrogens.
AE: N/V fever, headache, adrenal insufficency.

Question 4

Anastrozole

Answer 4

reversible nonsteroidal competitive aromatase inhibitor Prevents formation of estrogens.
AE: N/V, hot flashes, decreased bone density, increased appetite, polyarthralgia.

Question 5

Letrozole

Answer 5

reversible nonsteroidal competitive aromatase inhibitor Prevents formation of estrogens.
AE: N/V, hot flashes, decreased bone density, increased appetite, polyarthralgia.

Question 6

Tamoxifen

Answer 6

Competitive Estrogen receptor antagonist. benefit up to 5 years in ER+ tumors. AE: hot flashes, N/V, ENDOMETRIAL cancer

Question 7

Toremifine

Answer 7

Competitive estrogen receptor antagonist

AE: hot flashes, N/V, ENDOMETRIAL cancer

Question 8

Abiraterone Acetate

Answer 8

17a hydroxylase inhibitor. blocks conversion of pregnenolone and progesterone into 17a hydroxy forms preventing the formation of androgens and estrogens.
tx. metastatic prostate cancers.

Question 9

Degarelix

Answer 9

GNRH antagonist, causes immediate decrease in FSH, LH, T/E. No flare in response. generally well tolerated.

Question 10

Dutasteride

Answer 10

competitive 5 a reductase inhibitor. Decreases DHT production. treats BPH, Male pattern baldness, prevents prostate CA.
AE: impotentce, teratogenic.

Question 11

Exemestane

Answer 11

Suicide “steroidal” Aromatase inhibitor. prevents conversion of androgens to estrogens.

Question 12

Finasteride

Answer 12

competitive 5 a reductase inhibitor. Decreases DHT production. treats BPH, Male pattern baldness, prevents prostate CA.
AE: impotentce, teratogenic.

Question 13

Flutamide

Answer 13

antiandrogen, causes decreased androgen binding, and prevents translocation of receptor. leads to feedback increase in Testosterone, but no receptor available.
AE: short term admin in combo with GNRH analog to treat flare., N/V, diarrhea, sexual dysfunction, hot flashes, hepatotoxicity.

Question 14

Nalutamide

Answer 14

antiandrogen, causes decreased androgen binding, and prevents translocation of receptor. leads to feedback increase in Testosterone, but no receptor available.
AE: short term admin in combo with GNRH analog to treat flare., N/V, diarrhea, sexual dysfunction, hot flashes, hepatotoxicity.

Question 15

Raloxifene

Answer 15

Estrogen receptor antagonist in breast and uterus, agonist in bone, no risk of endometrial cancer.
AE: hot flashes, N/V,

Question 16

Bicalutamide

Answer 16

antiandrogen, causes decreased androgen binding, and prevents translocation of receptor. leads to feedback increase in Testosterone, but no receptor available.
AE: short term admin in combo with GNRH analog to treat flare., N/V, diarrhea, sexual dysfunction, hot flashes, hepatotoxicity.