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Hormone Drugs Flashcards

1
Q

Omnitrope

A

Recombinant human growth hormone

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2
Q

Nutropin

A

Recombinant human growth hormone

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3
Q

Norditropin

A

Recombinant human growth hormone

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4
Q

Genotropin

A

Recombinant human growth hormone

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5
Q

Siazen

A

Recombinant human growth hormone

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6
Q

Mecasermin

A

Recombinant IGF-1 which is a growth hormone (produced by liver) which causes bone growth in children at the epiphyseal plate.

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7
Q

Dopamine

A

along with somatostatin leads to decreased GNRH and prolactin release.

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8
Q

Bromocriptine

A

dopamine agonist leading to decreased growth hormone production.

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9
Q

Prolactin

A

Generated in the Anterior pituitary, causes milk let down, has no negative feedback

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10
Q

Oxytocin

A

Posterior pituitary, causes milk ejection

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11
Q

Thyroid hormone

A

Only peptide hormone to have an intracellular receptor

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12
Q

Levothyroxine

A

T4 drug replacement

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13
Q

Negative regulators of Thyroid hormone

A

Dopamine, somatostatin

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14
Q

Thyroid peroxidase

A

responsible for combining mono and di iodothyronine to make T3 and T4. T3 is more active than T4, T4 converted to T3 intracellularly by deiodinase

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15
Q

Thyroid binding globulin

A

Thyroid hormone carrier protein binds both T3 and T4, binds more hormone than albumin

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16
Q

Prophylthiouracil

A

Targets deiodinase 1 preventing activation of T4 to T3

17
Q

thyrotoxicosis

A

due to thyroid storm and excessive thyroid hormone in circulation. Treat with beta blocker, thioamides (antithyroid), corticosteroid.

18
Q

Liothyronine

A

T3 drug supplement

19
Q

Methimazole

A

Thioamide used to treat hyperthyroidism by inhibiting thyro-peroxidase preventing conversion of T4 to T3

20
Q

Carbimazole

A

Thioamide used to treat hyperthyroidism by inhibiting thyro-peroxidase preventing conversion of T4 to T3

21
Q

11-B-hydroxylase

A

responsible for the conversion of steroids to their active form

22
Q

Testing for hypercortisolism

A

dexamethasone challenge test. If ACTH drops, it is a primary adenoma, if ACTH with high dose still doesn’t drop, it is likely an ectopic ACTH tumor

23
Q

Cortisol

A

Active form of cortisone

24
Q

Hydrocortisone

A

Synthetic cortisone

25
Q

Prednisone

A

glucocorticoid

26
Q

Methylprednisone

A

more potent glucocorticoid

27
Q

Dexamethasone

A

Incredibly potent glucocorticoid with no mineralocorticoid effect

28
Q

Fludrocortisone

A

Incredibly strong mineralocorticoid, and strong glucocorticoid

29
Q

Ketoconazole

A

Inhibits side chain cleavage (rate limiting step of steroid synthesis) antifungal. prevents glucocorticoid and androgen synthesis.

30
Q

Metyrapone

A

Inhibits 11 Beta hydroxylase preventing activation of steroids

HRM (11 decks)

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