Downing Cells Female Test 2 Flashcards
Estrogen Producing Cells
Theca cells ad granulosa cells
Progesterone producing cells
Corpus luteum
OoGenesis progression
Oogonia, primary oocyte, secondary oocyte
Oogonia
46 chromosomes, original egg cell prior to birth
Primary Oocyte
46 chromosomes, are the eggs at birth, Arrested in Prophase I
Secondary Oocyte
23 Chromosomes, Arrested at Metaphase II, are the egg maturing and released at ovulation. 1 polar body produced to create secondary oocyte
Ova
Once fertilized, the secondary Oocyte rapidly divides producing another polar body.
Follicular Cells
Singer layer of flattened cells surrounding the primordial follicles, contain FSH receptors.
Primary Follicles
20-50 respond each menstrual cycle, surround primary oocyte. one follicle becomes dominant and rest undergo atresia
Secondary Follicles
begins to form antral space, primar oocyte. contains Theca folliculi
Theca interna
highly vascular theca falliculi layer of secondary follicle responsible for androgen production
Theca Externa
Fusiform cells and collagen, no known function
Mature follicles
LH surge signals final maturation, resumption of meiosis, primary oocyte becomes secondary and is arrested at metaphase II until fertilization. LH surge leads to ovulation and rupture of follicle.
FSH function
Granulosa cell growth and estrogen synthesis, Estrogen stimulates increase in LH receptors
LH
Stimulates thecal cell growth and androgen production, granulosa cells convert androgens to estrogens
Corpus luteum
Temporary glandular structure, thecal lutein cells secrete progesterone. If pregnancy occurrs, it is maintained by HCG, persists during first trimester.
Estrogen
Produced by growing follicles, induces maturation of female reproductive tract, incluences growth of mamary glands in pregnancy
Progesterone
Produced by the corpus luteum, causes uterus to secrete layer for endometrial lining, prepares uterus for implantation of fertilized ovum, inhibits uterine contractions
Relaxin
Produced by corpus luteum and decidual cells., inhibits contraction of myometrium during pregnancy, dilates cervix,
Inhibin
Produces follicular fluid, negative feedback on FSH production
Basal layer of endometrium
Responsible for regenerating functional layer of endometrium
Blood supply to endometrium
one to basal layer, one to endometrium
Proliferative phase
Begins at end of menstrual flow days 7-14, induced by estrogen, 2-3x increase in endometrial thickness, numerous mitoses in glands and stroma, coiled arteries elongate but do not reach superficial endometrium
Secretory Phase
days 15-26 ovulation precipitates corpus luteum formation, Increase in progesterone and then estrogen, endometrial thickening
coiled arteries elongate preparing for conceptus
Premenstrual phase
days 27-28, coiled arteries constrict, corpus luteum regresses, coiled arteries periodically constrict and then permanently constrict at day 28, endometrial detachement begins
menstrual phase
functional layer of endometriumm undergoes complete necrosis and is shed, venous seepage, clots- RBC aggregates
Cervical mucosa
not shed with menses, composed of columnar epithelium, produces mucus