M2. Chemoprophylaxis

Question 1

Criteria for effective chemoprophylaxis

Answer 1

1. Drug must be effective
2. Host have well defined increased risk of disease
3. drug safety outweigh risk
4. Drug must have adequate tissue conc. present at the time of exposure

Question 2

Chemoprophylaxis against infectious disease

Answer 2

1. TB
2. Lepto
3. Rabies
4. Neisseria meningitis
5. Rheuma heart disease

Question 3

DISEASEA TARGETED PROPHYLAXIS (G2K)

Answer 3

• Rheumatic fever
• Endocarditis
• Malaria
• Cholera
• Plague
• Influenza
• Leptospirosis

Question 4

During surgical prophylaxis give antibiotics __ hour prior to surger

Answer 4

1

Question 5

Rheumatic fever primary preventions

Answer 5

1. Treat streptococcal pharyngitis
2. Oral Penicillin V for 10 days
3. Oral Erythromycin for 10 days (if allergic)

Question 6

Rheumatic fever secondary preventions

Answer 6

1. Oral Penicillin V 250 BID
2. Erythromycin 250 BID
3. Benzathine Penicillin 1.2 M.U IM every 21 days.

Question 7

Standard oral regimen for endocarditis prophylaxis in adults with high risk cardiac lesions

Answer 7

Amoxicillin 2 gm by mouth 1 hour prior to

procedure

Question 8

Penicillin allergy for endocarditis prophylaxis in adults with high risk cardiac lesions

Answer 8

a. Clarithromycin, Azithromycin 500 mg
(1 hour prior to procedure)
b. Cefalexin 2 gm (1 hour prior )
c. Clindamycin 600 mg (1 hour prior)

Question 9

LATENT INFECTION TREATMENT for tuberculosis

Answer 9

1. INH 300 mg daily x 9 months or
2. INH + Rifampicin daily for 6 months or
3. Rifampicin for 4 months or
4. Rifampicin + Pyrazinamide for 2 months

Question 10

2 drug regimen for low risk HIV

Answer 10

1. Zidovudine

2. Lamivudine

Question 11

3 drug regimen for low risk HIV

Answer 11

1. Zidovudine
2. Lamivudine
3. Indinavir