Lysosomal jigsaw Flashcards
Describe the lysosomal system.
Describe protein trafficking to lysosomes.
Describe the secretory membrane system.
Why is lysosomal degradation important?
Describe autophagy with regards to the lysosomal pathway.
What are the common lysosomal storage diseases?
Why is autophagy important?
Gaucher Disease
What is the difference between GAGs and glycoproteins?
What is the difference between o-linked and n-linked glycosylation initiation?
D
What are glycosaminoglycans (GAGs) and how are they formed?
How are GAGs degraded in the body?
What are the diseases associated with inability to degrade GAGs called? What are the most common ones?
Lysosomal storage disorders
B and D
What targets the lysosomal hydrolases to the lysosome? Where does this occur?
What disease is associated with lysosomal hydrolase targeting?
C
How does the lysosome degrade compounds?
Why do lysosomal storage diseases occur? What is the molecular basis of the symptoms?
How are lipids classified? Which are important to Lysosomal storage disorders?
What are sphingophospholipids and how are they formed?
How are sphingophospholipids degraded? What lysosomal storage disorder is associated with this process?
What is the difference between type A and type B Niemann-Pick disease?
What are glycolipids and where are they found?
How do glycolipids and sphingomyelin differ?
What are the types of glycosphingophospholipids and how are they synthesized?
How are glycosphingophospholipids degraded?
lysosomal storage disease origin
How does the dysfunction of glycolipids degradation lead to tay-sachs and gaucher disease?
What are the disorders of degradation associated with sphingolipids?
What is the histological presentation of tay-sachs disease?
What is the histological presentation of Gaucher disease?
How are lysosomal storage disorders diagnosed and treated?
pathway of glycosphingophospholipid formation and degradatory issues
