13 - Nucleic Acid Metabolism

Question 1

What are the purines and pyrimidines?

Answer 1

Question 2

What are the functions of nucleotides?

Answer 2

Question 3

What are the most important steps in nucleotide synthesis?

Answer 3

R5P to nucleotide monophosphate. When you get to NMP you have determined fate for metabolism.

Question 4

How is generation of ATP/GTP regulated in nucleotide metabolism?

Answer 4

Question 5

Describe purine catabolism.

Answer 5

Question 6

What is the clinical significance of defective purine metabolism?

Answer 6

Question 7

Explain the basis for SCID in nucleotide metabolism.

Answer 7

Question 8

Explain the basis for Gout in nucleotide metabolism and describe hallmarks, symptoms, and treatment of Gout.

Answer 8

Question 9

What is the molecular basis for Von Gierke disease and how does that affect nucleotide metabolism?

Answer 9

Question 10

How can purine bases be recycled?

Answer 10

Question 11

What is the disease associated with purine nucleotide salvage?

Answer 11

Question 12

What are the purine metabolic disorders?

Answer 12

Question 13

Describe de novo pyrimidine synthesis.

Answer 13

Question 14

What is the clinical relevance of pyrimidine biosynthesis?

Answer 14

Question 15

How is UMP from pyrimidine synthesis used? How is pyrimidine synthesis regulated?

Answer 15

Question 16

How do you convert the Ribose sugars to deoxyribose sugars?

Answer 16

Question 17

What is the clinical relevance of the synthesis of deoxynucleotide diphosphates from nucleotide diphosphates (deoxyribose sugars from ribose sugars)?

Answer 17

Question 18

How do you change deoxyuridine monophosphate (dUMP) into a DNA base? How is this relevant clinically?

Answer 18

Question 19

How can you take advantage of nucleotide metabolism to treat nucleotide metabolic disorders?

Answer 19

Question 20

How are pyrimidines degraded?

Answer 20

Question 21

How are pyrimidines salvaged/recycled?

Answer 21