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Hematology > Lymphoma II > Flashcards

Lymphoma II Flashcards

1
Q

What are the ages of Hodgkin’s lymphoma?

A

20-30, then >50

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2
Q

Who gets hodgkin’s lymphoma?

A

Male caucasians

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3
Q

What is the survival rate of Hodgkin’s disease?

A

85%

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4
Q

What are the two associated infectious agents with Hodgkin’s lymphoma?

A

EBV and HIV

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5
Q

What are the ssx of Hodgkin’s disease?

A

fevers/chills/night sweats/weight loss
Pruritis
EtOH induced pain in lymph nodes

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6
Q

What are the common areas of lymphadenopathy of Hodgkin’s disease?

A

70% cervical

60% mediastinal

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7
Q

What is the major difference in lymphadenopathy between Hodgkin’s and NHL?

A

Contiguous in HL

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8
Q

True or false: unilateral bone marrow biopsy for HL is sufficient

A

True

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9
Q

What is stage I HD?

A

1 nodal region or lymph node

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10
Q

What is stage II HD?

A

2 or more nodal regions on the same side of diaphragm

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11
Q

What is stage III HD?

A

Both sides of the diaphragm

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12
Q

What is stage IV HD?

A

> 1 extranodal sites

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13
Q

What is a Reed Sternberg cell?

A

B cell origin with multinuclei (owl eyes)

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14
Q

What are the two CD markers for HD?

A

CD15 and CD30

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15
Q

What are the markers for adverse prognostic factor for HD?

A

Albumin 15

Hb

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16
Q

What is the prognosis for HL disease?

A

Very good

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17
Q

What are the treatments for HD?

A

Chemo + XRT. One alone if low grade, both if advanced

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18
Q

Which is more common: NHL or HL?

A

NHL

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19
Q

Who is usually affected by NHL?

A

Adult, white men

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20
Q

What are the two types of NHL?

A

B cell (85%) and T cell (15%)

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21
Q

What is the 5 year survival for NHL?

A

67%

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22
Q

What are the infectious agents that are implicated with NHL?

A 
EBV
HTLV-1
HCV
HHV8
H.pylori
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23
Q

What are the occupations/exposures of NHL? (3)

A

Agriculture
Benzene exposure
Prior Chemo/radiation

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24
Q

What are the ssx of NHL?

A

b-sx, but more symptoms if aggressive

25
Q

When is an LP indicated for NHL?

A

testicular, nasopharyngeal involvement

26
Q

What is the translocation for follicular lymphoma? Oncogene?

A

t(14;18)

bcl-2

27
Q

What is the translocation for SLL? Oncogene?

A

t(14;19)

bcl3

28
Q

What is the translocation for mantle cell lymphoma? Oncogene?

A

t(11;14)

bcl1

29
Q

What is the translocation for burkitt’s lymphoma? Oncogene?

A

t(8;14)

myc

30
Q

What is the translocation for DLCL? Oncogene?

A

t(3;14)

bcl6

31
Q

What are the two very aggressive NHLs?

A

Burkitt’s

Any T cell

32
Q

What is diffuse large cell lymphomas?

A

Rapidly enlarging mass with extranodal sites

33
Q

What is the overall cure rate of diffuse large cell lymphoma?

34
Q

What are the prognostic factors for diffuse large cell NHL?

A

LDH elevated
Age >60
>1 extranodal site

35
Q

What is the treatment for diffuse large cell NHL?

A

Chemo + rituxan

NOT surgical

36
Q

What is the chemo treatment for DLCL?

A

Cyclophosphamide
Adriamycin
Vincristine
Prednisone

37
Q

What is the MOA of rituximab?

A

Anti CD20 ab that targets DLCL

38
Q

What is small lymphocytic lymphoma? (ssx)

A

Indolent CA with enlarging LN over months to years

Usually asymptomatic

39
Q

Who gets SLL?

A

Late to middle aged

40
Q

What is the prognosis for SLL?

41
Q

What is Richter’s transformation?

A

about 35% of follicular lymphomas will transform into DLCL at 10 years of disease

42
Q

What is the treatment for indolent lymphoma, SLL?

A

Curative radiation therapy if early stages

Palliative radiation + chemo if advanced stages

43
Q

What are the three very aggressive NHLs?

A

Lymphoblastic lymphoma
Burkitt’s lymphoma
Any T cell lymphoma

44
Q

Who usually gets very aggressive NHL?

A

Peds and young adults

45
Q

What is the prognosis for very aggressive NHLs?

A

Curable, but very aggressive

46
Q

Who gets a stem cell/BM transplant for aggressive lymphoma? What type of transplant is this?

A

DLCL, follicular, and very aggressive lymphomas

Autologous stem cells

47
Q

What is MALT lymphoma? Where is this usually found?

A

Mucosa associated lymphoid tissue lymphoma

GI tract, lungs, breasts

48
Q

What is the treatment for MALT d/t h.pylori?

A

usual treatment for H.pylori

Chemo if not spontaneous remission after

49
Q

What are the three HIV associated lymphoma?

A

DLCL
Burkitt’s
CNS lymphoma

50
Q

Where are HIV associated lymphoma found?

A

Anus/rectum

Soft tissues

51
Q

What is the major prognosis factor for HIV associated lymphoma?

A

Low CD4 counts

52
Q

Who gets CLL?

A

Older pts with immunodeficiency conditions

53
Q

Which type of lymphocyte is associated with CLL?

54
Q

Where is CLL found in the body?

A

Always in bone marrow and peripheral blood

55
Q

What are the ssx of CLL?

A

Asymptomatic to infectious symptoms

Lymphadenopathy/splenomegaly

56
Q

What are the labs like i CLL?

A

Leukocytosis

Low IgG, IgA and IgM

57
Q

What are the CD markers for CLL?

A

CD5
CD20
CD23

58
Q

What is stage 0 - 4 of CLL?

A 
0 = lymphocytosis
1 = Lymphadenopathy
2 = Splenomegaly
3 = Anemia
4 = thrombocytopenia
59
Q

What is the prognosis for CLL? Treatment?

A

Not curable, but treat with chemo when high stage or very symptomatic

Hematology (32 decks)

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