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HEM Exam 3 > Lymphoma > Flashcards

Lymphoma Flashcards

1
Q

lymph nodes in Hodgkin’s lymphoma

A
  • continuous lymph node group to contiguous lymph node group
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2
Q

diffuse large B-cell lymphoma cytogenetic abnormalities? molecular abnormalities?

A
  • no cytogenetic abnormalities
  • abnormal Bcl-6
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3
Q

small lymphocytic lymphoma flow cytometry

A
  • CD5 and CD23 present
  • light chain restricted
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4
Q

follicular hyperplasia has a need for

A
  • antibody production
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5
Q

most common type of non-hodgkin’s lymphoma

A
  • diffuse large B-cell lymphoma
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6
Q

follicular small cleaved lymphoma may progress to

A
  • large cell lymphoma
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7
Q

paracortical hyperplasia has an increased need for

A
  • cell-mediated immunityq
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8
Q

lymphoma pathology classification schemes

A
  • working formulation
  • WHO
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9
Q

follicular small cleaved lymphoma curability

A
  • incurable
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10
Q

Burkitt’s lymphoma affects which population

A
  • children
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11
Q

paracortical hyperplasia expansion of

A
  • paracortical activity
  • increased mitotic activity
  • activated lymphocytes
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12
Q

Burkitt’s lymphoma affects which cell

A
  • mature B cell
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13
Q

two or more nodal regions of an extra nodal site on the same side of the diagraphragm is what stage

A

II

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14
Q

lymphoblastic lymphoma affects which cell

A
  • immature T cells expressing CD3
  • coexpressing CD4 and CD8
  • and TdT
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15
Q

diffuse large B-cell lymphoma can be associated with

A
  • immune dysfunctional
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16
Q

diffuse large B-cell lymphoma curability of low stage

A
  • low stage can be cured
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17
Q

sinus histiocytosis stimulation of

A
  • antigen-presenting cells
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18
Q

Hodgkin lymphoma flow cytometry nor cytogenetics

A
  • not diagnostic
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19
Q

mantle cell lymphoma translocation

A
  • t(11;14)
  • cyclin D1 gene
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20
Q

follicular small cleaved lymphoma affects which population

A
  • middle-aged to elderly adults
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21
Q

intermediate grade lymphomas

A
  • diffuse large cell lymphoma
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22
Q

low grade lymphomas

A
  • small lymphocytic lymphoma
  • follicular small cleaved lymphoma
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23
Q

risk factors of most patients with non-hodgkin lymphoma

A
  • most patients have no identifiable risk factors
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24
Q

mantle cell lymphoma flow cytometry

A
  • CD5 and CD19 positive
  • CD10 and CD23 negative

MY BOY CORCH ROCKED NUMBER 5 FOR STATE AT 19 YEARS OLD. HE WOULD GO ON MY MANTLE ABOVE MJ AND HIS 10+ CHAMPIONSHIPS BECAUSE WE ARE STATE FANS.

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25
Q

trisomy 12 small lymphocytic lymphoma prognosis

A
  • bad
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26
Q

light chains expressed by flow cytometry of normal lymph nodes

A
  • B cells express both kappa and lambda light chains
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27
Q

Burkitt’s lymphoma translocation

A
  • t(8;14)
  • t(2;8)
  • t(8:22)
  • c-myc
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28
Q

follicular small cleaved lymphoma affects which cell

A
  • mature B cell
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29
Q

Hodgkin lymphoma diagnosis based on

A
  • finding Reed-sternberg cells
30
Q

paracortical hyperplasia is the proliferation of

A
  • T lymphocytes
31
Q

lymphoblastic lymphoma affects which population

A
  • children
32
Q

mantle cell lymphoma expresses high levels of

A
  • cyclin D1
33
Q

sinus histiocytosis example

A
  • lymph nodes draining a carcinoma
34
Q

diffuse large B-cell lymphoma occurs in which population

A
  • children
  • adults
35
Q

lymphoblastic lymphoma flow cytometry

A
  • positive for CD4 and CD8
36
Q

sinus histiocytosis expansion of

A
  • subcapsular/medullary sinus
37
Q

Reed-Sternberg cell is what kind of cell

A
  • activated B cell
38
Q

Hodgkin lymphoma smaller peak incidence

A
  • >50s
39
Q

13q14 small lymphocytic lymphoma prognosis

A
  • good
40
Q

liver or bone marrow involvement or extensive involvement of another extralymphatic organ is what stage

A

IV

41
Q

follicular hyperplasia is the proliferation of

A
  • B lymphocytes
42
Q

single nodal region or a single extra nodal site is what stage

A

I

43
Q

non-hodgkin lymphoma associated infections

A
  • HIV
  • EBV
  • H.pylori
  • Hep B and C
  • HTLV-1
  • HHV-8
44
Q

Hodgkin lymphoma flow immunochemistry

A
  • positive for CD30 and CD15
  • negative for CD45
45
Q

small lymphocytic lymphoma affects what population

A
  • adults
46
Q

small lymphocytic lymphoma is the essentially the same disease as

A
  • CLL
47
Q

non-hodgkin lymphoma risk factors

A
  • age
  • infections
  • immune disorders
  • toxins
48
Q

sinus histiocytosis is proliferation of

A
  • histiocytes
  • tissue macrophages
49
Q

flow cytometry of normal lymph nodes

A
  • mixture of B and T cells
  • T cells express either CD4 or CD8
50
Q

non-hodgkin lymphoma associated toxic chemicals

A
  • pesticides - herbicides - benzenes
51
Q

curability of small lymphocytic lymphoma

A
  • incurable
52
Q

follicular hyperplasia example

A
  • neck nodes in a patient with strep throat
53
Q

small lymphocytic lymphoma affects what cell

A
  • mature B cell
54
Q

how do you distinguish A stage from B stage?

A

A stage is the absence of the B stage symptoms

55
Q

follicular small cleaved lymphoma grade

A
  • low grade
56
Q

follicular small cleaved lymphoma flow cytometry light chain

A
  • light chain restricted
  • only kappa or lambda
57
Q

follicular small cleaved lymphoma translocation

A
  • t(14;18)
  • BCL2

FAUX LICK. IT’S A FAUX PAS FOR A 14 YEAR OLD TO LICK AN 18 YEAR OLD. SHIT, ITS PROBABLY ILLEGAL TOO. AND YOU KNOW WHAT COMES AFTER LICKING, 2 BASTARD CHILDREN (BCL2)

58
Q

B symptoms

A
  • fever > 38 degrees
  • drenching night sweats
  • weight loss > 10% over 6 months
59
Q

what is the most common cause of enlarged lymph nodes?

A
  • benign reactive lymphadenopathy
60
Q

high grade lymphomas

A
  • burkitt’s lymphoma
  • lymphoblastic lymphoma
61
Q

paracortical hyperplasia example

A
  • neck nodes in patients with infectious mono
62
Q

mantle cell lymphoma occurs in which population

A
  • middle aged to elderly adults
63
Q

follicular small cleaved lymphoma - patients present with

A
  • high stage disease
64
Q

Hodgkin lymphoma characterized by presence of

A
  • Reed-sternberg cell
65
Q

lymphatic involvement on both sides of the diaphragm is what stage?

A

III

66
Q

Hodgkin lymphoma peak incidence

A
  • 20s
67
Q

follicular hyperplasia enlargement of

A
  • germinal center
  • tangible-body macrophages
  • increased mitotic activity
68
Q

Burkitt’s lymphoma closely related to

A
  • ALL FAB L3
69
Q

most non-hodgkin lymphoma is what type of cell

A
  • B cells
70
Q

lymphoblastic lymphoma presents with what symptom

A
  • mediastinal mass

HEM Exam 3 (20 decks)

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