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HEM Exam 3 > Lymphoma > Flashcards

Lymphoma Flashcards

1
Q

lymph nodes in Hodgkin’s lymphoma

A
  • continuous lymph node group to contiguous lymph node group
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2
Q

diffuse large B-cell lymphoma cytogenetic abnormalities? molecular abnormalities?

A
  • no cytogenetic abnormalities
  • abnormal Bcl-6
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3
Q

small lymphocytic lymphoma flow cytometry

A
  • CD5 and CD23 present
  • light chain restricted
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4
Q

follicular hyperplasia has a need for

A
  • antibody production
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5
Q

most common type of non-hodgkin’s lymphoma

A
  • diffuse large B-cell lymphoma
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6
Q

follicular small cleaved lymphoma may progress to

A
  • large cell lymphoma
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7
Q

paracortical hyperplasia has an increased need for

A
  • cell-mediated immunityq
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8
Q

lymphoma pathology classification schemes

A
  • working formulation
  • WHO
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9
Q

follicular small cleaved lymphoma curability

A
  • incurable
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10
Q

Burkitt’s lymphoma affects which population

A
  • children
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11
Q

paracortical hyperplasia expansion of

A
  • paracortical activity
  • increased mitotic activity
  • activated lymphocytes
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12
Q

Burkitt’s lymphoma affects which cell

A
  • mature B cell
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13
Q

two or more nodal regions of an extra nodal site on the same side of the diagraphragm is what stage

A

II

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14
Q

lymphoblastic lymphoma affects which cell

A
  • immature T cells expressing CD3
  • coexpressing CD4 and CD8
  • and TdT
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15
Q

diffuse large B-cell lymphoma can be associated with

A
  • immune dysfunctional
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16
Q

diffuse large B-cell lymphoma curability of low stage

A
  • low stage can be cured
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17
Q

sinus histiocytosis stimulation of

A
  • antigen-presenting cells
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18
Q

Hodgkin lymphoma flow cytometry nor cytogenetics

A
  • not diagnostic
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19
Q

mantle cell lymphoma translocation

A
  • t(11;14)
  • cyclin D1 gene
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20
Q

follicular small cleaved lymphoma affects which population

A
  • middle-aged to elderly adults
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21
Q

intermediate grade lymphomas

A
  • diffuse large cell lymphoma
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22
Q

low grade lymphomas

A
  • small lymphocytic lymphoma
  • follicular small cleaved lymphoma
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23
Q

risk factors of most patients with non-hodgkin lymphoma

A
  • most patients have no identifiable risk factors
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24
Q

mantle cell lymphoma flow cytometry

A
  • CD5 and CD19 positive
  • CD10 and CD23 negative

MY BOY CORCH ROCKED NUMBER 5 FOR STATE AT 19 YEARS OLD. HE WOULD GO ON MY MANTLE ABOVE MJ AND HIS 10+ CHAMPIONSHIPS BECAUSE WE ARE STATE FANS.

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25
trisomy 12 small lymphocytic lymphoma prognosis
- bad
26
light chains expressed by flow cytometry of normal lymph nodes
- B cells express both kappa and lambda light chains
27
Burkitt's lymphoma translocation
- t(8;14) - t(2;8) - t(8:22) - c-myc
28
follicular small cleaved lymphoma affects which cell
- mature B cell
29
Hodgkin lymphoma diagnosis based on
- finding Reed-sternberg cells
30
paracortical hyperplasia is the proliferation of
- T lymphocytes
31
lymphoblastic lymphoma affects which population
- children
32
mantle cell lymphoma expresses high levels of
- cyclin D1
33
sinus histiocytosis example
- lymph nodes draining a carcinoma
34
diffuse large B-cell lymphoma occurs in which population
- children - adults
35
lymphoblastic lymphoma flow cytometry
- positive for CD4 and CD8
36
sinus histiocytosis expansion of
- subcapsular/medullary sinus
37
Reed-Sternberg cell is what kind of cell
- activated B cell
38
Hodgkin lymphoma smaller peak incidence
- \>50s
39
13q14 small lymphocytic lymphoma prognosis
- good
40
liver or bone marrow involvement or extensive involvement of another extralymphatic organ is what stage
IV
41
follicular hyperplasia is the proliferation of
- B lymphocytes
42
single nodal region or a single extra nodal site is what stage
I
43
non-hodgkin lymphoma associated infections
- HIV - EBV - H.pylori - Hep B and C - HTLV-1 - HHV-8
44
Hodgkin lymphoma flow immunochemistry
- positive for CD30 and CD15 - negative for CD45
45
small lymphocytic lymphoma affects what population
- adults
46
small lymphocytic lymphoma is the essentially the same disease as
- CLL
47
non-hodgkin lymphoma risk factors
- age - infections - immune disorders - toxins
48
sinus histiocytosis is proliferation of
- histiocytes - tissue macrophages
49
flow cytometry of normal lymph nodes
- mixture of B and T cells - T cells express either CD4 or CD8
50
non-hodgkin lymphoma associated toxic chemicals
- pesticides - herbicides - benzenes
51
curability of small lymphocytic lymphoma
- incurable
52
follicular hyperplasia example
- neck nodes in a patient with strep throat
53
small lymphocytic lymphoma affects what cell
- mature B cell
54
how do you distinguish A stage from B stage?
A stage is the absence of the B stage symptoms
55
follicular small cleaved lymphoma grade
- low grade
56
follicular small cleaved lymphoma flow cytometry light chain
- light chain restricted - only kappa or lambda
57
follicular small cleaved lymphoma translocation
- t(14;18) - BCL2 FAUX LICK. IT'S A FAUX PAS FOR A 14 YEAR OLD TO LICK AN 18 YEAR OLD. SHIT, ITS PROBABLY ILLEGAL TOO. AND YOU KNOW WHAT COMES AFTER LICKING, 2 BASTARD CHILDREN (BCL2)
58
B symptoms
- fever \> 38 degrees - drenching night sweats - weight loss \> 10% over 6 months
59
what is the most common cause of enlarged lymph nodes?
- benign reactive lymphadenopathy
60
high grade lymphomas
- burkitt's lymphoma - lymphoblastic lymphoma
61
paracortical hyperplasia example
- neck nodes in patients with infectious mono
62
mantle cell lymphoma occurs in which population
- middle aged to elderly adults
63
follicular small cleaved lymphoma - patients present with
- high stage disease
64
Hodgkin lymphoma characterized by presence of
- Reed-sternberg cell
65
lymphatic involvement on both sides of the diaphragm is what stage?
III
66
Hodgkin lymphoma peak incidence
- 20s
67
follicular hyperplasia enlargement of
- germinal center - tangible-body macrophages - increased mitotic activity
68
Burkitt's lymphoma closely related to
- ALL FAB L3
69
most non-hodgkin lymphoma is what type of cell
- B cells
70
lymphoblastic lymphoma presents with what symptom
- mediastinal mass

HEM Exam 3 (20 decks)

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