Clinical Malignant Hematology Flashcards
1
Q
what happens in leukostasis
A
- WBCs plug the microvasculature
- decreased tissue perfusion
2
Q
what condition is leukostasis seen in
A
- acute leukemias
3
Q
treatment of leukostasis
A
- IV fluids
- decrease tumor burden
- lower uric acid levels
4
Q
how do we decrease tumor burden
A
- hydroxyurea
- leukapheresis
5
Q
how do we lower uric acid levels?
A
- allopurinol
- rasburicase
6
Q
what is tumor lysis syndrome
A
- mass tumor cell lysis resulting in extracellular and intracellular electrolytes + DNA
7
Q
tumor lysis syndrome is most common with what conditions
A
- Burkett’s lymphoma
- T-ALL
8
Q
what is hypercalcemia of malignancy
A
- bones
- abdominal groans
- psychiatric overtones
9
Q
what condition do we normally see DIC in
A
- APL
10
Q
microbiology associated with neutropenic fever
A
- more common gram positive
- pseudomonas gram negative
11
Q
hyper viscosity syndrome is a rare complication of what condition?
A
- waldenstrom’s macroglobulinemia
12
Q
what happens in hyper viscosity syndrome?
A
- increases in globulins raises serum viscosity
13
Q
treatment of hyper viscosity syndrome
A
- phasmapheresis
- chemotherapy
14
Q
spinal cord compression and cauda equina syndrome due to
A
- myeloma
- NHL
- solid tumors
15
Q
treatment of cauda equina
A
- glucocorticoids
- radiation
