Chemotherapy Pharmacology - FUCK THIS ENTIRE LECTURE MY STEPDAD SAID IT TOOK HIM 4 YEARS TO LEARN THESE THINGS AND HE JUST LOOKS THEM UP ON HIS PHONE Flashcards by Jean-Luc Banks

Q

vinca alkaloids toxicity

A

neurotoxicities - myelosuppression

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Q

bevacizumab target

A

VEGF

BEV THE FUCKING VEGAN

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Q

what kind of chemo is alkylating agents

A

nonspecific

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Q

toxicity of bevacizumab

A

proteinuria - GI perforation

BEV THAT FUCKING VEGAN PEES OUT PROTEIN AND HAS A PERF BOWEL

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Q

vinca alkaloids target what phase of the cell cycle

A

M phase

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Q

alkylator toxicities

A

myelosuppression - nausea/vomiting - secondary malignancy - infertility/impaired fertility - hemorrhagic cystitis

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Q

capecitabine drug

A

oral fluorouracil prodrug

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Q

administration of cell cycle specific chemo

A

continuous infusion - multiple divided doses

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Q

type of chemo of busulfan

A

alkylating agents

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Q

what kind of chemo drug is letrozole

A

aromatase inhibitor

LET US SMELL

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Q

bicalutamide is what kind of chemo drug

A

antiandrogen

BI ANDROGEN

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Q

vinca alkaloids MOA

A

microtubular destruction

VINCE LIKE VENDICTIVE AND WANTING TO DESTROY

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Q

which enzyme is response for recoiling DNA after transcription has occured

A

topo II

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Q

vincristine type of chemo

A

vinca alkaloid

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Q

Moa of abieraterone

A

androgen biosynthesis inhibitor

BI A BEER AND ANYONE TURNS GAY

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Q

what kind of chemo drug is exemestane

A

aromatase inhibitor (irreversible)

XMEN OFTEN CAN’T SMELL THE AROMA OF ANYTHING

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Q

fludarabine type of chemo

A

purine antagonist

PURE AS THE FLU

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Q

muromonab is what kind of monoclonal antibody

A

murine

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Q

cell cycle nonspecific agents exert their effects

A

at any phase of the cell cycle

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Q

what kind of chemo is anthracyclines

A

nonspecific

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Q

high dose II type of chemo

A

immunotherapy

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Q

ipilimumab type of chemo

A

immunotheratpy

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Q

type of chemo of chlorambucil

A

alkylating agents

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Q

pembrolizumab target

A

anti PD1

THE PD IS LIKELY TO GET THEIR ASS TARGETED IN PEMBROKE

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cell cycle specific chemotherapies in resting phase

- not active

topoisomerase II toxicities

- myelosuppression - secondary malignancies - dose dependent mucositis

cetuximab target

- EGFR EXACTLY GRAND FUCKING RIGHT I LOOK GOOD IN THIS TUX

which drug causes nausea/vomiting

- cisplatin

fluorouracil toxicities of bolus

- myelosuppression

hormonal therapy for prostate cancer

- antiandrogens - LHRH agonists - GnRH antagonist - CYP17 inhibitors

panitumumab is what kind of monoclonal antibody

- human

nilutamide is what kind of chemo drug

- antiandrogen nude without dudes (since androgens are for dudes)

oxaliplatin is a

- platinum compound

what kind of chemo drug is fulvestrant

- anti-estrogen NOT FULL OF BABY NOW

sipuleucel type of chemo

- immunotherapy

which drug causes cold sensitivity

- oxaliplatin COLD AS AN OX

fluorouracil given as

- bolus - continuous IV infusion

nivolumab target

- anti PD1 VOLUME LOUD LIKE A POLICE CAR PD

cetuximab use

- solid tumors LOOKING SOLID IN THAT TUX, SIR

what kind of chemo are taxanes

- cell cycle specific

what kind of chemo drug is megestrol acetate

- anti-estrogen MEG LIKE THE MEGALADON WHICH IS FUCKING SCARY AND SO IS A VAGINA

capecitabine toxicity

- hand-foot syndrome POP A CAP IN THAT HAND AND FOOT

what anthracycline treats most solid tumors?

- doxorubicin

toxicities of platinum compounds

- peripheral neuropathies - nephrotoxicities - nausea/vomiting - thrombocytopenia

paclitaxel type of chemo

- taxane

what metabolite produces hemorrhagic cystitis

- acrolein

degarelix is what kind of chemo drug

- GnRH antagonist SOUNDS LIKE DEGRASSI A BIT AND I WATCHED THAT AT NIGHT. GN GOOD NIGHT RED HEAD

type of chemo of melphalan

- alkylating agents

which drug causes pulmonary problems

- BCNu BE SEEING YOU, LUNGS!

type of chemo of cyclophosphamide

- alkylating agents

toxicity of cetuximab

- hypersensitive reaction - acneiform rash SEE HE IS HYPERSENSITIVE ABOUT HIS TUX BECAUSE IT COVERS HIS RASH

rituximab use

- lymphomas

antimetabolites MOA

- inhibit DNA replication or repair

hormone therapies for breast cancer

- anti-estrogens - aromatase inhibitors

BCNu is a

- nitrosourea

leuprolide is what kind of chemo drug

- LHRH agonist LUE LIKE LUKE BRYAN ALSO PROBABLY LOW HUNG REALLY HUNG

topotecan type of chemo

- camptothecins

what kind of chemo are vincas

- cell cycle specific

topoisomerase II inhibitors

- etoposide - teniposide NIP SLIP UP TOP OF SECOND STORY OF TOPO

what kind of chemo is platinum agents

- nonspecific

methotrexate MOA

- inhibition of DHFR - tumor cells rely solely on endogenous folate for growth

sipuleucel target

- T

what chemo class is associated with pulmonary toxicity

- bleomycin

antimetabolites specificity

- S phase

trastuzumab target

- Her-2 TRUST HER2

what kind of chemo is mitoxantrone

- anthracycline HAS ANTR SO THAT HELPS

folate antagonists

- methotrexate - pemetrexed (Alimta)

abiraterone is what kind of chemo drug

- CYP17 inhibitors A BI RAT CAME OUT AT 17

anthracyclines MOA

- intercalate DNA and inhibits topoisomerase

which drug causes nephrotoxicity

- cisplatin

carboplatin is a

- platinum compound

trastuzumab use

- breast cancer DON'T TRUST A HOE - 3OH!3

trastuzumab is what kind of monoclonal antibody

- humanized

what kind of chemo are antimetabolites

- cell cycle specific

fluorouracil toxicities of continuous infusion

- GI

what kind of chemo drug is tamoxifen

- anti-estrogen FIXIN' TO FUCK THAT BABY UP

flutamide is what kind of chemo drug

- antiandrogen

what kind of chemo is epirubicin

- anthracyclines EPI LIKE ANTRAX

pembrolizumab type of chemo

- immunotherapy PEOPLE IN PEMBROKE THINK THEY ARE IMMUNE TO EVERYTHING

topoisomerase inhibitors

- camptothecins

gemcitabine type of chemo

- purine antagonist PURE AS A GEM

vinblastine type of chemo

- vinca alkaloid

which drug causes CNS problems

- BCNu with EtOH dilution

CCNu is a

- nitrosourea

irinotecan type of chemo

- camptothecins TECANS ARE ALL THECINS

interferon type of chemo

- immunotherapy

pyrimidine analogues

- fluorouracil - capecitabine

nitrosoureas toxicities

- pulmonary - myelosuppression - nausea/vomiting - phlebitis - CNS

high dose cytarabine toxicies

- cerebellar - conjunctivitis

taxane toxicity

- myelosuppression - peripheral neuropathies - hypersensitivity

taxane MOA

- micro tubular stabilization TAXES MAKE YOU STABLE - A COMPLETE FUCKING LIE BUT WHATEVER WORKS

what kind of chemo is daunorubicin

- anthracyclines CYCLE BEFORE DAWN

anthracyclines secondary mechanism

- free radical damage

which drug causes thrombocytopenia

- carboplatin CARBO THROMBO

which drugs are fatal if administered intrathecally

- vinca alkaloids

treatment for ifosfamide

mesna

rituximab is what kind of monoclonal antibody

- chimeric

cetuximab is what kind of monoclonal antibody

- chimeric

leucovorin/fluorouracil MOA

- LCV increases binding of FU to thymidylate synthetase - inhibits converts of dUMP to dTMP

what antracycline treats breast cancer

- epirubicin EPIRUB SOUNDS LIKE EPIBOOB AND IDK I'M TIRED

6-mercaptopurine type of chemo

- purine antagonist

what kind of chemo is doxorubicin

- anthracyclines

cisplatin is a

- platinum compound

what drug usually causes hemorrhagic cystitis

- ifosfamide iFUCKED UP

ipilimumab target

- anti-CTLA-4 - immune checkpoint inhibitor

rituximab target

- CD20

which enzyme is responsible for relaxing supercoiled DNA to allow transcription to occur

- topo I

vinorelbine type of chemo

- vinca alkaloid

cell cycle nonspecific agents toxic effects occur

- during the cell cycle

toxicities of methotrexate

- mucositis - myelosuppression

toxicities of anthracyclines

- myelosuppression - cardiac toxicity - mucositis - extravasation

goserelin is what kind of chemo drug

- LHRH agonist RYAN GOSLING IS A LOW HUNG REALLY HUNG AGONIST

cell cycle specific chemotherapies effect exerted on

- dividing cells only

what kind of chemo drug is anastrozole

- aromatase inhibitor NAS LIKE NASAL SO AROMA

cladribine type of chemo

- purine antagonist

cytarabine

- pyrimidine antagonists

docetaxel type of chemo

- taxane TAXEL TAXANE THIS ONE IS FUCKING EASY

toxicity of captothecins

- myelosuppression - diarrhea captured by the toilet with diarrhea

bevacizumab is what kind of monoclonal antibody

- humanized

nivolumab type of chemo

- immunotherapy

what kind of chemo is nitrosoureas

- nonspecific

bevacizumab use

- solid tumors BEV THE FUCKING VEGAN IS SOLID BECAUSE SHE EATS SO HEALTHY

what anthracycline treats acute leukemias

- daunorubicin - idarubicin

type of chemo of thiotepa

- alkylating agents AKYLS ARE THOTS AND SO IS THIOTEPA

anthracyclines toxicities

- cumulative, dose-dependent biventricular heart failure

type of chemo of mechlorethane

- alkylating agents

cell cycle nonspecific agents toxic effects expressed

- expressed during any attempt at cell division

type of chemo of ifosfamide

- alkylating agents

Moa of alkylating agents

- direct cross linking of base pairs