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HEM Exam 3 > Chemotherapy Pharmacology - FUCK THIS ENTIRE LECTURE MY STEPDAD SAID IT TOOK HIM 4 YEARS TO LEARN THESE THINGS AND HE JUST LOOKS THEM UP ON HIS PHONE > Flashcards

Chemotherapy Pharmacology - FUCK THIS ENTIRE LECTURE MY STEPDAD SAID IT TOOK HIM 4 YEARS TO LEARN THESE THINGS AND HE JUST LOOKS THEM UP ON HIS PHONE Flashcards

1
Q

vinca alkaloids toxicity

A
  • neurotoxicities - myelosuppression
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2
Q

bevacizumab target

A
  • VEGF

BEV THE FUCKING VEGAN

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3
Q

what kind of chemo is alkylating agents

A
  • nonspecific
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4
Q

toxicity of bevacizumab

A
  • proteinuria - GI perforation

BEV THAT FUCKING VEGAN PEES OUT PROTEIN AND HAS A PERF BOWEL

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5
Q

vinca alkaloids target what phase of the cell cycle

A
  • M phase
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6
Q

alkylator toxicities

A
  • myelosuppression - nausea/vomiting - secondary malignancy - infertility/impaired fertility - hemorrhagic cystitis
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7
Q

capecitabine drug

A
  • oral fluorouracil prodrug
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8
Q

administration of cell cycle specific chemo

A
  • continuous infusion - multiple divided doses
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9
Q

type of chemo of busulfan

A
  • alkylating agents
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10
Q

what kind of chemo drug is letrozole

A
  • aromatase inhibitor

LET US SMELL

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11
Q

bicalutamide is what kind of chemo drug

A
  • antiandrogen

BI ANDROGEN

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12
Q

vinca alkaloids MOA

A
  • microtubular destruction

VINCE LIKE VENDICTIVE AND WANTING TO DESTROY

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13
Q

which enzyme is response for recoiling DNA after transcription has occured

A
  • topo II
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14
Q

vincristine type of chemo

A
  • vinca alkaloid
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15
Q

Moa of abieraterone

A
  • androgen biosynthesis inhibitor

BI A BEER AND ANYONE TURNS GAY

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16
Q

what kind of chemo drug is exemestane

A
  • aromatase inhibitor (irreversible)

XMEN OFTEN CAN’T SMELL THE AROMA OF ANYTHING

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17
Q

fludarabine type of chemo

A
  • purine antagonist

PURE AS THE FLU

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18
Q

muromonab is what kind of monoclonal antibody

A
  • murine
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19
Q

cell cycle nonspecific agents exert their effects

A
  • at any phase of the cell cycle
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20
Q

what kind of chemo is anthracyclines

A
  • nonspecific
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21
Q

high dose II type of chemo

A
  • immunotherapy
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22
Q

ipilimumab type of chemo

A
  • immunotheratpy
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23
Q

type of chemo of chlorambucil

A
  • alkylating agents
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24
Q

pembrolizumab target

A
  • anti PD1

THE PD IS LIKELY TO GET THEIR ASS TARGETED IN PEMBROKE

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25
Q

cell cycle specific chemotherapies in resting phase

A
  • not active
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26
Q

topoisomerase II toxicities

A
  • myelosuppression - secondary malignancies - dose dependent mucositis
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27
Q

cetuximab target

A
  • EGFR

EXACTLY GRAND FUCKING RIGHT I LOOK GOOD IN THIS TUX

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28
Q

which drug causes nausea/vomiting

A
  • cisplatin
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29
Q

fluorouracil toxicities of bolus

A
  • myelosuppression
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30
Q

hormonal therapy for prostate cancer

A
  • antiandrogens - LHRH agonists - GnRH antagonist - CYP17 inhibitors
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31
Q

panitumumab is what kind of monoclonal antibody

A
  • human
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32
Q

nilutamide is what kind of chemo drug

A
  • antiandrogen

nude without dudes (since androgens are for dudes)

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33
Q

oxaliplatin is a

A
  • platinum compound
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34
Q

what kind of chemo drug is fulvestrant

A
  • anti-estrogen

NOT FULL OF BABY NOW

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35
Q

sipuleucel type of chemo

A
  • immunotherapy
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36
Q

which drug causes cold sensitivity

A
  • oxaliplatin

COLD AS AN OX

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37
Q

fluorouracil given as

A
  • bolus - continuous IV infusion
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38
Q

nivolumab target

A
  • anti PD1

VOLUME LOUD LIKE A POLICE CAR PD

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39
Q

cetuximab use

A
  • solid tumors

LOOKING SOLID IN THAT TUX, SIR

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40
Q

what kind of chemo are taxanes

A
  • cell cycle specific
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41
Q

what kind of chemo drug is megestrol acetate

A
  • anti-estrogen

MEG LIKE THE MEGALADON WHICH IS FUCKING SCARY AND SO IS A VAGINA

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42
Q

capecitabine toxicity

A
  • hand-foot syndrome

POP A CAP IN THAT HAND AND FOOT

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43
Q

what anthracycline treats most solid tumors?

A
  • doxorubicin
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44
Q

toxicities of platinum compounds

A
  • peripheral neuropathies - nephrotoxicities - nausea/vomiting - thrombocytopenia
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45
Q

paclitaxel type of chemo

A
  • taxane
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46
Q

what metabolite produces hemorrhagic cystitis

A
  • acrolein
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47
Q

degarelix is what kind of chemo drug

A
  • GnRH antagonist

SOUNDS LIKE DEGRASSI A BIT AND I WATCHED THAT AT NIGHT. GN GOOD NIGHT RED HEAD

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48
Q

type of chemo of melphalan

A
  • alkylating agents
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49
Q

which drug causes pulmonary problems

A
  • BCNu

BE SEEING YOU, LUNGS!

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50
Q

type of chemo of cyclophosphamide

A
  • alkylating agents
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51
Q

toxicity of cetuximab

A
  • hypersensitive reaction - acneiform rash

SEE HE IS HYPERSENSITIVE ABOUT HIS TUX BECAUSE IT COVERS HIS RASH

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52
Q

rituximab use

53
Q

antimetabolites MOA

A
  • inhibit DNA replication or repair
54
Q

hormone therapies for breast cancer

A
  • anti-estrogens - aromatase inhibitors
55
Q

BCNu is a

A
  • nitrosourea
56
Q

leuprolide is what kind of chemo drug

A
  • LHRH agonist

LUE LIKE LUKE BRYAN ALSO PROBABLY LOW HUNG REALLY HUNG

57
Q

topotecan type of chemo

A
  • camptothecins
58
Q

what kind of chemo are vincas

A
  • cell cycle specific
59
Q

topoisomerase II inhibitors

A
  • etoposide - teniposide

NIP SLIP UP TOP OF SECOND STORY OF TOPO

60
Q

what kind of chemo is platinum agents

A
  • nonspecific
61
Q

methotrexate MOA

A
  • inhibition of DHFR - tumor cells rely solely on endogenous folate for growth
62
Q

sipuleucel target

63
Q

what chemo class is associated with pulmonary toxicity

64
Q

antimetabolites specificity

65
Q

trastuzumab target

A
  • Her-2

TRUST HER2

66
Q

what kind of chemo is mitoxantrone

A
  • anthracycline

HAS ANTR SO THAT HELPS

67
Q

folate antagonists

A
  • methotrexate - pemetrexed (Alimta)
68
Q

abiraterone is what kind of chemo drug

A
  • CYP17 inhibitors

A BI RAT CAME OUT AT 17

69
Q

anthracyclines MOA

A
  • intercalate DNA and inhibits topoisomerase
70
Q

which drug causes nephrotoxicity

71
Q

carboplatin is a

A
  • platinum compound
72
Q

trastuzumab use

A
  • breast cancer

DON’T TRUST A HOE - 3OH!3

73
Q

trastuzumab is what kind of monoclonal antibody

74
Q

what kind of chemo are antimetabolites

A
  • cell cycle specific
75
Q

fluorouracil toxicities of continuous infusion

76
Q

what kind of chemo drug is tamoxifen

A
  • anti-estrogen

FIXIN’ TO FUCK THAT BABY UP

77
Q

flutamide is what kind of chemo drug

A
  • antiandrogen
78
Q

what kind of chemo is epirubicin

A
  • anthracyclines

EPI LIKE ANTRAX

79
Q

pembrolizumab type of chemo

A
  • immunotherapy

PEOPLE IN PEMBROKE THINK THEY ARE IMMUNE TO EVERYTHING

80
Q

topoisomerase inhibitors

A
  • camptothecins
81
Q

gemcitabine type of chemo

A
  • purine antagonist

PURE AS A GEM

82
Q

vinblastine type of chemo

A
  • vinca alkaloid
83
Q

which drug causes CNS problems

A
  • BCNu with EtOH dilution
84
Q

CCNu is a

A
  • nitrosourea
85
Q

irinotecan type of chemo

A
  • camptothecins

TECANS ARE ALL THECINS

86
Q

interferon type of chemo

A
  • immunotherapy
87
Q

pyrimidine analogues

A
  • fluorouracil - capecitabine
88
Q

nitrosoureas toxicities

A
  • pulmonary - myelosuppression - nausea/vomiting - phlebitis - CNS
89
Q

high dose cytarabine toxicies

A
  • cerebellar - conjunctivitis
90
Q

taxane toxicity

A
  • myelosuppression - peripheral neuropathies - hypersensitivity
91
Q

taxane MOA

A
  • micro tubular stabilization

TAXES MAKE YOU STABLE - A COMPLETE FUCKING LIE BUT WHATEVER WORKS

92
Q

what kind of chemo is daunorubicin

A
  • anthracyclines

CYCLE BEFORE DAWN

93
Q

anthracyclines secondary mechanism

A
  • free radical damage
94
Q

which drug causes thrombocytopenia

A
  • carboplatin

CARBO THROMBO

95
Q

which drugs are fatal if administered intrathecally

A
  • vinca alkaloids
96
Q

treatment for ifosfamide

97
Q

rituximab is what kind of monoclonal antibody

98
Q

cetuximab is what kind of monoclonal antibody

99
Q

leucovorin/fluorouracil MOA

A
  • LCV increases binding of FU to thymidylate synthetase - inhibits converts of dUMP to dTMP
100
Q

what antracycline treats breast cancer

A
  • epirubicin

EPIRUB SOUNDS LIKE EPIBOOB AND IDK I’M TIRED

101
Q

6-mercaptopurine type of chemo

A
  • purine antagonist
102
Q

what kind of chemo is doxorubicin

A
  • anthracyclines
103
Q

cisplatin is a

A
  • platinum compound
104
Q

what drug usually causes hemorrhagic cystitis

A
  • ifosfamide

iFUCKED UP

105
Q

ipilimumab target

A
  • anti-CTLA-4 - immune checkpoint inhibitor
106
Q

rituximab target

107
Q

which enzyme is responsible for relaxing supercoiled DNA to allow transcription to occur

108
Q

vinorelbine type of chemo

A
  • vinca alkaloid
109
Q

cell cycle nonspecific agents toxic effects occur

A
  • during the cell cycle
110
Q

toxicities of methotrexate

A
  • mucositis - myelosuppression
111
Q

toxicities of anthracyclines

A
  • myelosuppression - cardiac toxicity - mucositis - extravasation
112
Q

goserelin is what kind of chemo drug

A
  • LHRH agonist

RYAN GOSLING IS A LOW HUNG REALLY HUNG AGONIST

113
Q

cell cycle specific chemotherapies effect exerted on

A
  • dividing cells only
114
Q

what kind of chemo drug is anastrozole

A
  • aromatase inhibitor

NAS LIKE NASAL SO AROMA

115
Q

cladribine type of chemo

A
  • purine antagonist
116
Q

cytarabine

A
  • pyrimidine antagonists
117
Q

docetaxel type of chemo

A
  • taxane

TAXEL TAXANE THIS ONE IS FUCKING EASY

118
Q

toxicity of captothecins

A
  • myelosuppression - diarrhea

captured by the toilet with diarrhea

119
Q

bevacizumab is what kind of monoclonal antibody

120
Q

nivolumab type of chemo

A
  • immunotherapy
121
Q

what kind of chemo is nitrosoureas

A
  • nonspecific
122
Q

bevacizumab use

A
  • solid tumors

BEV THE FUCKING VEGAN IS SOLID BECAUSE SHE EATS SO HEALTHY

123
Q

what anthracycline treats acute leukemias

A
  • daunorubicin - idarubicin
124
Q

type of chemo of thiotepa

A
  • alkylating agents

AKYLS ARE THOTS AND SO IS THIOTEPA

125
Q

anthracyclines toxicities

A
  • cumulative, dose-dependent biventricular heart failure
126
Q

type of chemo of mechlorethane

A
  • alkylating agents
127
Q

cell cycle nonspecific agents toxic effects expressed

A
  • expressed during any attempt at cell division
128
Q

type of chemo of ifosfamide

A
  • alkylating agents
129
Q

Moa of alkylating agents

A
  • direct cross linking of base pairs

HEM Exam 3 (20 decks)

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