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Histo Block 3 > lymphatic review deck > Flashcards

lymphatic review deck Flashcards

1
Q

describe what is found in each part of LN

A

cortex- afferents, B cells
paracortex- HEVs, T cells
Medullae- efferents, B cells

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2
Q

what is the clinical relevance of the sub capsular sinus?

A

site of CA mets, macrophages on patrol

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3
Q

how much blood or lymph must be filtered to generate an antigenic response?

A

5%

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4
Q

what are present in splenic sinusoids?

A

rod cells, macrophages

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5
Q

how does the spleen receive blood?

A

central arteriole with PALS

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6
Q

where are Hassal’s corpuscles found?

A

thymic medulla

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7
Q

where are NKCs stored?

A

liver, blood, spleen

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8
Q

what region of the antibody will bind to the immune cell?

A

Fc region on the heavy chain

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9
Q

what links the heavy and light chains of the antibody?

A

disulfide bonds

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10
Q

what are the 4 functions of antibodies?

A

identify
opsonize
neutralize
clear infection

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11
Q

which antibody is assoc with mucosa and breast milk?

A

IgA

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12
Q

which antibody crosses placenta?

A

IgG

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13
Q

describe MHC-I

A

present on most cells, presents to killer T cells

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14
Q

describe MHC-II

A

present only on APCs (macrophages, b cells and dendritic cells), present to T cells

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15
Q

how is they thymus structurally different from all other lymph tissues?

A

it is not supported by reticular fibers, it instead has thymic epithelial cells

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16
Q

where are the thymic epithelial cells most concentrated?

A

cortex of thymus

17
Q

what is the fxn of thymic epithelial cells?

A

secrete polypeptides

structure/support

18
Q

what is the structure of the blood-thymus barrier?

A

continuous capillaries, 2 basal laminae, thymic epithelial cells all held together with tight junctions

19
Q

how do immature T cells reach the thymus?

A

circulatory system

20
Q

is the thymus a lymph filter?

A

no, as it lacks afferent lymphatics

21
Q

describe follicular dendritic cells

A

present in follicles

present antigens on MHC-I

22
Q

how does most lymph enter secondary lymphatic tissues?exception?

A

via High endothelial venules, except for spleen

23
Q

where are cancer cells first noted in LN?

A

subcapsular sinus

24
Q

what is a defining feature of tonsils, in general?

A

crypts

25
Q

what differentiates palatine from pharyngeal tonsils?

A

palatine- strat squamous

pharyngeal- pseudostrat columnar

26
Q

what is the only GALT discussed?

A

peyer’s patches

27
Q

where are peer’s patches exclusively found?

A

ileum

28
Q

describe the structure of peer’s patches

A

M cells overlie lymph nodules, B and T cells enter through HEVs, dendritic cells present antigens, B cells produce IgA

29
Q

what is the predominant cell type in PALS?

A

t cells

30
Q

how does most lymph enter LNs?

A

through HEV in the paracortex

31
Q

is the lymph tissue in the appendix encapsulated or unencapsulated?

A

unencapsulated

32
Q

what is appendix considered?

A

MALT

33
Q

what is d-MALT? o-MALT?

A

diffuse MALT

organized MALT

34
Q

what are the 4 functions of the spleen?

A
  • filter blood, look for antigens
  • produce B/T cells
  • destroy old RBCs
  • extramedullary hematopoiesis (pathologic)
35
Q

what part of the antibody determines the “class”?

A

Heavy chain, Fc region

36
Q

what does the spleen notable lack?

A

HEVs

37
Q

what type of cells produce reticular fibers in lymph tissue?

A

fibroblast-like reticular cells

38
Q

what are LN considered lymph filters?

A

because they contain macrophages that filter lymph for particulates, FDCs and antigens

39
Q

what is the only lymph tissue that filters blood?

A

spleen

Histo Block 3 (11 decks)

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