Lymph/immune Flashcards
What are examples of pathogens
Viruses, bacteria, fungi, & parasites
Immunity definition
Ability to resist infection & disease
How do lymph vessels move lymph
Skeletal muscle pump, one way valves, respiratory pump
Function of lymph system
Produce, maintain, and distribute lymphocytes
Production site of lymphocytes
Bone marrow, tonsils, spleen, thymus
Lymphatic capillaries compared to blood capillaries
Larger diameter, flat, thinner walls, start as pockets
Lacteals function
Transports lipids from digestive tract
Where are lacteals found
Small intestines
Where do lymph vessels end
Right lymphatic ducts, & thoracic duct
Where does thoracic duct collect lymph from?
Left brachiomediastinal trunk, left subclavian trunk, left jugular trunk
Where does thoracic duct empty lymph
Into left subclavian vein
Where does right lymphatic duct empty lymph
Right subclavian vein
Where does right lymphatic duct collect lymph
Right jugular trunk, right subclavian trunk, right brachiomediastinal trunk
Lymphedema
Severe swelling caused by Blockage of lymph drainage from a limb
What do cytotoxic cells do
Kill infected cells
Function of memory T cells
Immunity,fights a second infection of the same type much quicker
Function of helper T cells
Connects innate immune system and specific immunity
Suppressor T cells function
Inhibit immunity
Antigen
Anything that causes an immune response
Function of NK cells
Fights foreign, virus-infected, and cancer cells
Lymphopoeisis
Production of lymphocytes
What structures are involved in lymphopoeisis
Bone marrow, thymus, and spleen
What causes B cell differentiation
Interleukin, a cytokine
Function of lymph node
Filter, removes debris, pathogens, and antigen
Lymphadenopathy
Enlargement of lymph nodes
What causes lymphadenopathy
Infections, endocrine disorders, or cancers
When does thymus atrophy occur
After puberty
What is in red pulp
Red blood cells and macrophages
What is in white pulp
Lymphocytes
What are some categories of innate defense
Mech/chem barriers, phagocytes, interferons, complement, inflammatory response, fever, & immunological surveillance.
What are examples of physical barriers
Nose hairs, earwax, urination
Example of immunological surveillance
NK cells
What is interferon
Chemical released from virus infected cells
What is complement
A protein that stains the germ making it easier to kill
What are signs of inflammatory responses
Edema, redness, heat, pain, and loss of function
Why do we get fevers
To raise the body temperature to kill germs
Emigration/diapedesis
How white blood cells move through capillaries
Chemotaxis
What leukocytes use to recognize germs
How do NK cells react to infected cells
Secrete perforin killing the cell but not the virus
what triggers Classical pathway of complement system
Antibodies attach to antigen and acts as an enzyme causing a cascade
What event starts the classical pathway
C1 binding to antibodies
What does alternative pathway of complement system do
Make the germ visible by leaving a chemical trail
What do both complement pathways end with
C3b on surface of germs
Opsonization
Tagging of foreign pathogens
What factors attract macrophages to an area
Swelling, redness, heat, and pain
What do mast cells do
Release histamine and heparin
Tolerance
Immune system ignores self antigens
What happens if immune system loses tolerance
Autoimmune diseases
Function of Major histocompatibility complex
How we identify one another using DNA matching
Where is MHC class 1 found
Membrane of all nucleated cells
Where is class 2 of MHC
Found in membranes of antigen presenting cells & lymphocytes
What cells are considered antigen presenting cells
Macrophages and B cells
What occurs when cytotoxic cells dividing due to class 1 activation
Production of memory T cells
What produces cytokines for immune system?
Helper T cells
Interleukin function
Communication between specific defense systems (level 4 & 3)
Hapten
Piece of an antigen
What has to happen for a Hapten to become a complete antigen
Must attach to carrier molecules
Epitote
The location of an antigen
-AKA antigenic determinant
What activates in primary response
(And the order)
IgM first and then IgG
What occurs in secondary response
IgG and IgM arise quicker and become more efficient
(IgG comes in first)
When can fetus produce immune response
3-4 months
How does IgG get to fetus
Placenta
How does IgA get to child from mother
Breast milk
Examples of immune deficiency diseses
SCID, and AIDS
What causes allergies
Allergy causing antigens
What occurs due to high stimulation of mast cells
Massive release of histamine
What happens if histamine is in the body in large quantities
Vessel dilation, and airway constriction
Anaphylactic shock
T/F) the immune system declines with age
True
Adhesion (macrophages)
When phagocytes attach to germ
Acute compartment syndrome
Swelling caused by compression