Endocrine Chart Flashcards
Which APH is released by corticotropin releasing hormone CRH
Adrenocorticotropic hormone
Target 1 and hormone of Adrenocorticotropic hormone ACTH
Adrenal cortex (zone fasculata)
Glucocorticoids e.g. cortisol
Target 2 of Adrenocorticotropic hormone
Adipose, all cells, liver, immune system
Action of Adrenocorticotropic hormone overall
Overall: more fuel
High levels of Adrenocorticotropic hormone causes?
Cushing syndrome
Low levels of Adrenocorticotropic hormone ACTH
Addison disease-bronzed, reddish skin
What APH (anterior pituitary hormone) is released by growth hormone releasing hormone
Growth hormone aka somatropin
Target 1 and hormone of growth hormone
Liver- release insulin-Like growth factors (lGFs)
Target 2 of growth hormone
All body tissues
Action of growth hormone
Overall more fuel for growth
High levels of growth hormone causes?
Pituitary gigantism (children), acromegaly (adults)
Low levels of growth hormone causes
Pituitary dwarfism
What APH is released by thyrotropin-releasing hormone
Thyroid stimulating hormone TSH
Target 1 and hormone of thyroid stimulating hormone?
Thyroid
Thyroid hormone (t3 and t4) -follicular cells
Target of thyroid hormone
All cells
Action of thyroid hormone on all cells
All cells: increased metabolic rate, protein synthesis, glucose uptake
Action of thyroid hormone on the liver
Glycogen breakdown, glucose synthesis from noncarbs, glucose release.
Action of thyroid stimulating hormone on adipose cells
Increased Triglyceride breakdown
Action of thyroid stimulating hormone on the heart
Increased heart rate, and contractile force
High levels of thyroid stimulating hormone causes?
Graves disease
Low levels of thyroid stimulating hormone causes?
Hypothyroidism (cretinism (children), myxedema (adults))
Golter
What hormone releases prolactin
Prolactin releasing hormone
Target of prolactin
Breast
Action of prolactin
Mammary duct secretion and gland development
Which hormones are released by gonadotropin-releasing hormones
Follicle-stimulating hormone (FSH)
Luteinizing hormone (LH)
Target 1 and hormone of follicle stimulating hormone for males
Testes (sertoli cells)
Hormone: inhibin, androgen-binding protein
Target of inhibin and androgen binding protein for males
Testes kidneys and hypothalamus
Action of follicle stimulating hormone for males
Testes: with androgen binding protein, testosterone stimulates sperm production
Target 1 and hormone of follicle stimulating hormone for females
Ovary
Hormone: Estrogen
Target 2 of follicle stimulating hormone for females
Uterus, hypothalamus, breast, kidney, all cells
Action of follicle stimulating hormone for females on uterus
Builds endometrial lining
Action of follicle stimulating hormone for females on all cells
Increases protein production (egg development)
Action of estrogen for females on hypothalamus
NEGATIVE FEEDBACK
Inhibit GnRH/FSH (moderate estrogen)
POSITIVE FEEDBACK
stimulate GnRH/FSH (high estrogen)
Action of follicle stimulating hormone for females on breast and kidneys
Develop mammary glands, kidney: retains Na+/H2O
Target 1 and hormone luteinizing hormone for females
Ovary (corpus luteum)
Hormone: progesterone
Target 2 of progesterone for females
Uterus, mammary glands, kidney.
Action of progesterone for females
Uterus: build/maintain endometrial lining
Progesterone (ovulation)
Target 1 and hormone for luteinizing hormone for males
Testes (interstitial cells)
Hormone: testosterone
Target testosterone for males
All cells with testosterone receptors and bones
Action of luteinizing hormone for males
All cells: increase protein anabolism, increase sex drive, secondary sex characteristics.
Bone: stimulate bone formation
Action of Adrenocorticotropic hormone ACTH on liver and immune system
Liver: glucose synthesis from non carbs/ glucose release
Immune system: anti-inflammatory
Action of cortisol on all cells and fat cells
All cells: increased protein breakdown
Adipose: increased triglyceride breakdown
Action of growth hormone on all body tissue and adipose
All body tissues: growth
Adipose: triglyceride breakdown
Action of growth hormone on liver
Glycogen breakdown, glucose synthesis from non carbs, glucose release.
What produces the antidiuretic hormone
Hypothalamus supraoptic nucleus
What stores the antidiuretic hormone ADH
Posterior pituitary
Where does the antidiuretic hormone ADH go to
Kidney, hypothalamus thirst center, blood vessels
What is the action of antidiuretic hormone ADH
Kidney: decrease urine output
Hypothalamus: stimulate thirst, constrict blood vessels
What happens when there is no release of ADH?
Diabetes insipidus could occur
Where is oxytocin produced?
Hypothalamus paraventricular nucleus
Where is oxytocin stored?
Posterior pituitary
Where does the oxytocin hormone go?
Uterus, mammary gland, brain
What is the action of oxytocin
Uterus: stimulate contraction during delivery,
mammary gland: stimulate to let milk down
Brain: increase emotional bonding
Where does the insulin hormone come from?
Pancreas beta cells (islets of langerhans)
Where does insulin go
Liver, adipose tissue, skeletal muscle
Action of insulin for the kidney
Increased glycogen storage
Action of insulin for the adipose tissue
Increase triglycerides storage
Action of insulin for the skeletal muscle
Increased glycogen storage, and calcium uptake
Action of insulin for all cells
Increased protein synthesis, an glucose uptake
What does insulin do overall
Lower blood glucose levels (Diabetes 1 and 2 are related to this hormone)
Where does glucagon come from
pancreas alpha cells
Where does glucagon go to
Liver, adipose, and skeletal
What does glucagon do to the liver
Decreases glycogen storage, increases glucose synthesis from noncarbs
What does glucagon do to adipose
Decreased triglyceride storage
What are the actions of glucagon on skeletal muscles
Decreased glycogen storage
What does glucagon do to the body overall
Increase blood glucose level
Where does PTH come from?
Parathyroid chief cells
Where does PTH go to?
Bone, kidney
Action of erythropoietin on the kidney
Increased Ca2+ excretion increases erythrocyte production
Action of PTH on the bone
Increased osteoclast activity,
Action of PTH on the kidney
Decreased Ca2+ excretion and increased PO43- excretion, activate calcitriol
Overall effect of PTH
Increases blood Ca2+
Where does calcitonin come from?
Thyroid parafollicular cells
Where does calcitonin go to?
Bone and kidney
Action of calcitonin on bones
Decreases osteoclast activity, and increases Ca2+ deposited in bone
Action of calcitonin on kidney
Increases Ca2+ excretion
What does calcitonin do overall
Decreases blood Ca2+
Where does erythropoietin come from
Kidney (primarily), liver
Where does EPO go to?
Red bone marrow
What does EPO do
Increases erythrocyte production
What does EPO do overall
Increases oxygen amount in blood via increasing red blood cell production
Where does catecholamines (epinephrine, norepinephrine) come from?
Adrenal medulla
Where does catecholamines go to
Sympathetic nervous system
What do catecholamines do?
Increases fight or flight effects: pupil dilation, bronchial dilation, increased HR, inhibit digestion/ urination
Where does angiotensin 2 come from
Liver (after a process that included the lungs and the kidneys)
Where does angiotensin 2 go?
Blood vessels,, hypothalamus, adrenal cortex, kidney
Action of angiotensin 2?
Blood vessels: constrict
Kidney: decrease urine
Hypothalamus: stimulate thirst, release ADH
adrenal cortex: release aldosterone
Where does aldosterone come from?
Adrenal cortex- zonal globumerulosa
Where does aldosterone go?
Kidney
Action of Aldosterone?
Decrease Na+/H2O excretion, increases K+ excretion
Overall function of aldosterone
Maintains Na2+/K+ blood levels, maintain BP and volume
Where does Atrial natriuretic peptide come from
Atrial chambers of the heart
Where does ANP go to
Kidney, blood vessels, hypothalamus, adrenal cortex
Action of ANP on kidney
Increases sodium/ water excretion, inhibit renin release
Action of ANP on blood vessels
Dilation
Action of ANP on hypothalamus
Inhibit ADH release from posterior pituitary
Action of ANP on adrenal cortex
Inhibit aldosterone
Where does gastrin come from
Stomach-Enteroendocrine G cells
Where does gastrin go to?
Stomach, gallbladder, pancreas, intestines, pyloric sphincter.
What does gastrin do for the intestines
Small intestines: contraction
Large intestines: mass movement
What does gastrin do for the stomach
Increased secretions and motility
What does gastrin do for the gallbladder
Release bile
What does gastrin do for the pancreas
Secrete pancreatic juices
What does gastrin do for the sphincters
Relaxes iliocecal valve and pyloric sphincters
What does gastrin do overall
Digest
Where does secretin come from
Duodenal enteroendocrine cells
Where does secretin go to
Stomach, liver, pancreas
What is the action of secretin
Stomach: decreased secretions and motility
Liver/pancreas: increased bicarbonate in bile/ pancreatic juice
What is the overall action of secretin
Buffer acidic chyme
Where does Cholecystokinin come from
Duodenal enteroendocrine cells
Where does the cholecystokinin go
Stomach, pancreas, liver, and gallbladder
What is the action of CCK on the pancreas and liver
Secretion of pancreatic juices and bile
What is the action of CCK on the stomach
Decreased secretions and motility
What is the action of CCK on the gallbladder and sphincter
Contraction to release bile, hepato-pancreatic sphincter relaxes