Lupus Flashcards
SLE predisposing factors
- genetics
- hormonal - estrogen
- environment - smoking, drugs, UV, pollution, etc
Drug-induced lupus medications (acronym)
my pretty malar marking probably has a transient quality
methimazole
propylthiouracil
minocycline
methyldopa
procainamide
hydralazine
anti-TNF agents
terbinafine
isoniazid
quinidine
Which laboratory tests have high specificity for lupus?
anti-dsDNA antibody
anti-Smith antibody
SLICC diagnostic requirements
must meet ≥ 4 total features with 1 from each group (clinical and immunological)
What is the backbone treatment of SLE?
Hydroxychloroquine
If someone has G6PD deficiency, which medication should they not take?
hydroxychloroquine
HCQ side effects
- retinal toxicity - bullseye maculopathy
- neuropsychiatric effects
- QTc prolongation
- myopathy
- hypersensitivity rxn
- hypoglycemia
- hemolytic anemia - G6PD deficiency
Glucocorticoids place in therapy
adjunct treatment - if not response to HCQ or NSAIDs
Glucocorticoids side effects
- glaucoma
- increased BP
- increased risk of osteoporosis
- GI bleed, gastritis
- sleep disturbances
- weight gain
- increased BG/hyperglycemia
- topical steroid - skin atrophy, rosacea
Immunosuppressants place in therapy
- adjunct when disease gets more severe or to lower steroid dose
- insufficient response to HCQ
Which immunosuppressants are used for SLE?
- methotrexate
- azathioprine
- cyclophosphamide
- mycophenolate
All of the immunosuppressants have a side effect of increased risk of malignancy, EXCEPT
methotrexate
All of the immunosuppressants have these side effects in common:
bone marrow suppression
infection
Which immunosuppressant has the unique side effect of acute inflammatory syndrome (AIS)?
mycophenolate
Which immunosuppressant should you not use with a TPMT deficiency?
azathioprine
