Exam 2 - Lung Cancer Flashcards

1
Q

Which mutations are associated with smokers?

A

KRAS, BRAF

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2
Q

Which mutations typically do not have PD-1 expression?

A

EGFR
ALK
ROS-1

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3
Q

Which one is slower growing: SCLC or NSCLC?

A

NSCLC

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4
Q

Which type (SCLC/NSCLC) is more related to smoking?

A

SCLC

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5
Q

On top of chemotherapy (and daily radiation), what should patients with limited stage SCLC lung cancer receive?

A

prophylactic cranial radiation

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6
Q

What is the recommended treatment for limited SCLC?

A

daily radiation and a platinum doublet for 4-6 cycles (cisplatin/carboplatin + etoposide)

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7
Q

What toxicities are unique to cisplatin?

A

nephrotoxicity
ototoxicity

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8
Q

What is the recommended treatment for extensive SCLC?

A

platinum based combo chemotherapy + immunotherapy - examples:

  1. carboplatin + etoposide + atezolizumab
  2. carboplatin + etoposide + durvalumab
  3. cisplatin + etoposide + durvalumab
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9
Q

When is pembrolizumab used in SCLC?

A

for metastatic SCLC in patients who have progressed on platinum-based chemotherapy and at least 1 prior line of therapy, regardless of PD-1 status

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10
Q

Difference between limited and extensive SCLC

A

limited: confined to one side of chest
extensive: not confined to the side of chest of origin

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11
Q

A patient with limited SCLC is on a carboplatin, etoposide regiment. They come in for a check-up and CT scan shows bone and liver metastases. What should be added to their treatment?

A

Atezolizumab

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12
Q

Which TKI is used for EGFR mutation?

A

Osimertinib

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13
Q

Which TKI is used for KRAS mutation?

A

Sotorasib

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14
Q

Adjuvant chemotherapy regimen for non-squamous NSCLC

A

Cisplatin + pemetrexed

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15
Q

Which TKI is used for BRAF mutations?

A

Dabrafenib + trametinib

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