Exam 2 - Lung Cancer Flashcards
Which mutations are associated with smokers?
KRAS, BRAF
Which mutations typically do not have PD-1 expression?
EGFR
ALK
ROS-1
Which one is slower growing: SCLC or NSCLC?
NSCLC
Which type (SCLC/NSCLC) is more related to smoking?
SCLC
On top of chemotherapy (and daily radiation), what should patients with limited stage SCLC lung cancer receive?
prophylactic cranial radiation
What is the recommended treatment for limited SCLC?
daily radiation and a platinum doublet for 4-6 cycles (cisplatin/carboplatin + etoposide)
What toxicities are unique to cisplatin?
nephrotoxicity
ototoxicity
What is the recommended treatment for extensive SCLC?
platinum based combo chemotherapy + immunotherapy - examples:
- carboplatin + etoposide + atezolizumab
- carboplatin + etoposide + durvalumab
- cisplatin + etoposide + durvalumab
When is pembrolizumab used in SCLC?
for metastatic SCLC in patients who have progressed on platinum-based chemotherapy and at least 1 prior line of therapy, regardless of PD-1 status
Difference between limited and extensive SCLC
limited: confined to one side of chest
extensive: not confined to the side of chest of origin
A patient with limited SCLC is on a carboplatin, etoposide regiment. They come in for a check-up and CT scan shows bone and liver metastases. What should be added to their treatment?
Atezolizumab
Which TKI is used for EGFR mutation?
Osimertinib
Which TKI is used for KRAS mutation?
Sotorasib
Adjuvant chemotherapy regimen for non-squamous NSCLC
Cisplatin + pemetrexed
Which TKI is used for BRAF mutations?
Dabrafenib + trametinib
