Exam 2 - Prostate Cancer Flashcards
Most common histology type of prostate cancer
adenocarcinoma
Most common site of metastases in prostate cancer
Bone
Treatment options for localized disease:
- active surveillance
- radiation
- surgery
(may add ADT if high risk)
LHRH agonists acute toxicities
tumor flare (metastatic setting), gynecomastia, hot flashes, erectile dysfunction, edema, injection site reactions
LHRH agonists long-term toxicities
(similar to estrogen deprivation symptoms)
osteoporosis, fractures, obesity, insulin resistance, increased risk of both diabetes and CV events
Anti-androgens toxicities
diarrhea, hematuria
Which anti-androgen is the drug of choice and why?
Bicalutamide (Casodex) - long half-life and daily dosing
What is the goal level of testosterone after 1 month of using ADT?
< 50 ng/dL
Caution using enzalutamide in patients with history of….
Seizures
Patients need to take prednisone with which anti-androgen drug?
Abiraterone
Which androgen receptor antagonist offers potentially less toxicities than others?
Darolutamide
For men who at not high-risk, what age should they start prostate cancer screening?
50
If a man’s PSA ≥ 2.5 ng/mL, how often should they get screened?
annually
If a man’s PSA < 2.5 ng/mL, how often should they get screened?
every 2 years
What is an important factor in determining what treatment plan the patient receives with m1 disease?
low volume vs high volume
