Final Review

Question 1

Topo I inhibitors

Answer 1

irinotecan

Question 2

Topo II inhibitors

Answer 2

etoposide
doxorubicin
bleomycin

Question 3

microtubule destabilizers

Answer 3

vinca alkaloids (i.e. vincristine)

Question 4

microtubule stabilizers

Answer 4

taxanes (i.e. paclitaxel)

Question 5

Hodgkins lymphoma treatment options

Answer 5

1. ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine)
2. AAVD (bleomycin replaced with brentuximab vedotin)

Question 6

Non-Hodgkins lymphoma treatment options

Answer 6

1. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone)
2. Pola-R-CHP (polatuzumab vedotin, rituximab, cyclophosphoamide, doxorubicin, predisone)

Question 7

What are the B symptoms?

Answer 7

drenching night sweats
fever
weight loss

Question 8

Corrected calcium =

Answer 8

serum calcium + 0.8(4- serum albumin)

Question 9

What is present in 95% of CML cases?

Answer 9

philadelphia chromosome - BCR-ABL

Question 10

5HT-3 antagonists (i.e. ondansetron) adverse effects

Answer 10

headache
constipation
EKG changes

Question 11

Disadvantages/complications of PN:

Answer 11

1. pneumothorax (central PN)
2. air embolus (central PN)
3. infection/catheter-related sepsis
4. bacterial translocation
5. hyper- and hypoglycemia

Question 12

Bicarb dose (mEq) =

Answer 12

(0.5 mEq/L x IBW) x (desired (12) - actual)
THEN, give 1/3-1/2 of that dose

Question 13

Give bicarb if pH < ______

Answer 13

7.1

Question 14

Saline responsive metabolic alkalosis causes

Answer 14

1. diuretics
2. vomiting + NG suction
3. exogenous HCO3- (blood transfusions)

Question 15

Saline resistant metabolic alkalosis causes

Answer 15

1. mineralocorticoids
2. Hypokalemia
3. Renal tubular Cl- wasting

Question 16

Mild hypercalcemia =

Answer 16

10-12 mg/dL

Question 17

Moderate hypercalcemia =

Answer 17

12-14 mg/dL

Question 18

Severe hypercalcemia =

Answer 18

> 14 mg/dL

Question 19

Are renal dosing adjustments of bisphosphonates needed for HCM or SREs?

Answer 19

skeletal related events

Question 20

A patient’s pathology report indicates their tumor is a carcinoma with a high degree of dysplasia. What does this mean?

Answer 20

The tumor is derived from epithelial cells and there is a loss of normal tissue architecture.

Question 21

The development of drug resistance to multiple cancer chemotherapeutic drugs is most likely caused by?

Answer 21

Increased cellular efflux of drugs

Question 22

Treatment options for postmenopausal women with ER+ disease:

Answer 22

1. Tamoxifen
2. Aromatase inhibitors (steroidal and non-steroidal)
3. Estrogen antagonists (fulvestrant)

Question 23

Vinca alkaloids target which phase of the cell cycle?

Answer 23

G2/M

Question 24

Which of the following chemotherapies does not directly cause DNA damage?
A. Doxorubicin
B. Paclitaxel
C. Mitomycin C
D. Cisplatin

Answer 24

B. Paclitaxel

Question 25

You have a breast cancer patient whose tumor has tested positive for an EGFR mutation. Which of the following is a covalent inhibitor that could be indicated? A. Tucatinib B. Afatinib C. Binimetinib D. Acalabrutinib

Answer 25

B. Afatinib