Final Review Flashcards
Topo I inhibitors
irinotecan
Topo II inhibitors
etoposide
doxorubicin
bleomycin
microtubule destabilizers
vinca alkaloids (i.e. vincristine)
microtubule stabilizers
taxanes (i.e. paclitaxel)
Hodgkins lymphoma treatment options
- ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine)
- AAVD (bleomycin replaced with brentuximab vedotin)
Non-Hodgkins lymphoma treatment options
- R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone)
- Pola-R-CHP (polatuzumab vedotin, rituximab, cyclophosphoamide, doxorubicin, predisone)
What are the B symptoms?
drenching night sweats
fever
weight loss
Corrected calcium =
serum calcium + 0.8(4- serum albumin)
What is present in 95% of CML cases?
philadelphia chromosome - BCR-ABL
5HT-3 antagonists (i.e. ondansetron) adverse effects
headache
constipation
EKG changes
Disadvantages/complications of PN:
- pneumothorax (central PN)
- air embolus (central PN)
- infection/catheter-related sepsis
- bacterial translocation
- hyper- and hypoglycemia
Bicarb dose (mEq) =
(0.5 mEq/L x IBW) x (desired (12) - actual)
THEN, give 1/3-1/2 of that dose
Give bicarb if pH < ______
7.1
Saline responsive metabolic alkalosis causes
- diuretics
- vomiting + NG suction
- exogenous HCO3- (blood transfusions)
Saline resistant metabolic alkalosis causes
- mineralocorticoids
- Hypokalemia
- Renal tubular Cl- wasting
Mild hypercalcemia =
10-12 mg/dL
Moderate hypercalcemia =
12-14 mg/dL
Severe hypercalcemia =
> 14 mg/dL
Are renal dosing adjustments of bisphosphonates needed for HCM or SREs?
skeletal related events
A patient’s pathology report indicates their tumor is a carcinoma with a high degree of dysplasia. What does this mean?
The tumor is derived from epithelial cells and there is a loss of normal tissue architecture.
The development of drug resistance to multiple cancer chemotherapeutic drugs is most likely caused by?
Increased cellular efflux of drugs
Treatment options for postmenopausal women with ER+ disease:
- Tamoxifen
- Aromatase inhibitors (steroidal and non-steroidal)
- Estrogen antagonists (fulvestrant)
Vinca alkaloids target which phase of the cell cycle?
G2/M
Which of the following chemotherapies does not directly cause DNA damage?
A. Doxorubicin
B. Paclitaxel
C. Mitomycin C
D. Cisplatin
B. Paclitaxel
You have a breast cancer patient whose tumor has tested positive for an EGFR mutation. Which of the following is a covalent inhibitor that could be indicated?
A. Tucatinib
B. Afatinib
C. Binimetinib
D. Acalabrutinib
B. Afatinib
