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P3 Therapeutics > Final Review > Flashcards

Final Review Flashcards

1
Q

Topo I inhibitors

A

irinotecan

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2
Q

Topo II inhibitors

A

etoposide
doxorubicin
bleomycin

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3
Q

microtubule destabilizers

A

vinca alkaloids (i.e. vincristine)

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4
Q

microtubule stabilizers

A

taxanes (i.e. paclitaxel)

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5
Q

Hodgkins lymphoma treatment options

A
  1. ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine)
  2. AAVD (bleomycin replaced with brentuximab vedotin)
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6
Q

Non-Hodgkins lymphoma treatment options

A
  1. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone)
  2. Pola-R-CHP (polatuzumab vedotin, rituximab, cyclophosphoamide, doxorubicin, predisone)
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7
Q

What are the B symptoms?

A

drenching night sweats
fever
weight loss

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8
Q

Corrected calcium =

A

serum calcium + 0.8(4- serum albumin)

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9
Q

What is present in 95% of CML cases?

A

philadelphia chromosome - BCR-ABL

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10
Q

5HT-3 antagonists (i.e. ondansetron) adverse effects

A

headache
constipation
EKG changes

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11
Q

Disadvantages/complications of PN:

A
  1. pneumothorax (central PN)
  2. air embolus (central PN)
  3. infection/catheter-related sepsis
  4. bacterial translocation
  5. hyper- and hypoglycemia
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12
Q

Bicarb dose (mEq) =

A

(0.5 mEq/L x IBW) x (desired (12) - actual)
THEN, give 1/3-1/2 of that dose

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13
Q

Give bicarb if pH < ______

A

7.1

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14
Q

Saline responsive metabolic alkalosis causes

A
  1. diuretics
  2. vomiting + NG suction
  3. exogenous HCO3- (blood transfusions)
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15
Q

Saline resistant metabolic alkalosis causes

A
  1. mineralocorticoids
  2. Hypokalemia
  3. Renal tubular Cl- wasting
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16
Q

Mild hypercalcemia =

A

10-12 mg/dL

17
Q

Moderate hypercalcemia =

A

12-14 mg/dL

18
Q

Severe hypercalcemia =

A

> 14 mg/dL

19
Q

Are renal dosing adjustments of bisphosphonates needed for HCM or SREs?

A

skeletal related events

20
Q

A patient’s pathology report indicates their tumor is a carcinoma with a high degree of dysplasia. What does this mean?

A

The tumor is derived from epithelial cells and there is a loss of normal tissue architecture.

21
Q

The development of drug resistance to multiple cancer chemotherapeutic drugs is most likely caused by?

A

Increased cellular efflux of drugs

22
Q

Treatment options for postmenopausal women with ER+ disease:

A
  1. Tamoxifen
  2. Aromatase inhibitors (steroidal and non-steroidal)
  3. Estrogen antagonists (fulvestrant)
23
Q

Vinca alkaloids target which phase of the cell cycle?

A

G2/M

24
Q

Which of the following chemotherapies does not directly cause DNA damage?
A. Doxorubicin
B. Paclitaxel
C. Mitomycin C
D. Cisplatin

A

B. Paclitaxel

25
Q

You have a breast cancer patient whose tumor has tested positive for an EGFR mutation. Which of the following is a covalent inhibitor that could be indicated?
A. Tucatinib
B. Afatinib
C. Binimetinib
D. Acalabrutinib

A

B. Afatinib

P3 Therapeutics (16 decks)

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