LSD Flashcards
lysergic acid diethylamid(LSD)
a psychedelic hallucinogent
Dr.albert hoffman
first to synthesized LSD
he synthesized it while seeking a new drug therapy for migrain
absorbed accidently in his hand
effective
hallucination
time is subjective/contorsion
time course
psychedelicstate(stronger) , afterglow,residual effects
12 hours
two phases
early phase=psychedelic(seratonergic)- seratonin blockers - blocks hallucinations-ketanserin
late phase=paranoia(dopaminergic)
seratonin hypothasis of schizophrenia
1.the psychological effects of LSD are mediated by the seratonin receptor
2.seratonin2 receptor abnormalities are evident in the brains of individuals with schizopheenia and at-risk patients
3.seratonin receptor antagonism is known to contribute to the effect of atypical antipsychotics
P.E. Bleuler
coined the term schizophrenia - splitting of minds.