Liver Symposium Flashcards

1
Q

What type of hepatitis cause enteric viruses?

A

Hepatitis A

Hepatitis E

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2
Q

What type of hepatitis cause parenteral viruses?

A

Hepatitis D
Hepatitis C
Hepatitis D

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3
Q

What type of hepatitis cause chronic disease?

A

Hepatitis B
Hepatitis C
Hepatitis D

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4
Q

How is hepatitis A transmitted?

A

Faecal-oral
Sexual
Blood

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5
Q

Who gets immunisation fro Hepatitis A?

A

Travellers
Occupational exposure
Chronic liver disease patients
Men who have sex with men (MSM)

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6
Q

How is hepatitis B transmitted?

A

Vertical (mother to child)

Sexual

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7
Q

What is the make up of the hepatitis B vaccine?

A

Only contains surface antigens

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8
Q

What are the drugs used to treat hepatitis C?

A

Sofobuvir

Ledipasvir

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9
Q

What type of virus is hepatitis D?

A

RNA

Resistant to treatment and usually coinfects with HBV

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10
Q

What is the treatment for hepatitis E?

A

No specific treatment or effective vaccine and is self limiting

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11
Q

What are the different types of fatty liver disease?

A

Non alcoholic steatosis

Non alcoholic steatohepatitis

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12
Q

What are the risk factors for fatty liver disease`?

A
Diabetes 
Obesity 
Hypertension 
Hpercholesterolaemia 
Age 
Ethnicity (hispanic)
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13
Q

How do you diagnose fatty liver disease?

A
Biochemical tests (AST/ALT ratio) 
Ultrasound 
MRI/CT 
Liver biopsy 
Cytokeratin-18 
Scoring system used
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14
Q

How do you treat fatty liver disease?

A
Diet and weight reduction 
Exercise 
Insulin sensitisers 
Vitamin E 
Weight reduction surgery
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15
Q

What is autoimmune hepatitis?

A

Elevated IgG

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16
Q

How is autoimmune hepatitis treated?

A

Long term azathioprine

17
Q

What are the clinical signs of primary biliary cholangitis?

A

IgM elevated

Anti-mitochondrial antibody positive

18
Q

What is the treatment for primary biliary cholangitis?

A

UDCA treatment

19
Q

What are the clinical signs of primary sclerosing cholangitis?

A

pANCA positive
intra and extra hepatic bile ducts involvement
MRCP test

20
Q

How do you treat primary sclerosing cholangitis?

A

Biliary stents

21
Q

Who are the appropriate liver transplant candidates?

A

Hepatocellular carcinoma
Acute liver failure
Genetic diseases
Chronic liver disease with poor predicted survival and associated poor QOL

22
Q

What are the contraindications for liver transplant?

A

Malignancy
Active and uncontrolled infection
Active substance or alcohol abuse
Severe cardiopulmonary or other comorbid conditions

23
Q

What is the post operative liver transplant treatment?

A

ICU
Prophylactic antibiotics and anti fungal drugs
Anti rejection drugs (steroids, azathioprine, tacrolimus)

24
Q

What dose CAGE stand for?

A

Cut down
Annoyed by criticism of your drinking
Guilty about your drinking
Eyeopener

25
What os the presentation of alcoholic hepatitis?
Jaundice Encephalopathy Infection is common Decompensated hepatic function
26
What are the clinical signs of alcoholic hepatitis
Raised bilirubin Raised GGT and AlkP Alcohol history
27
What is the treatment for alcoholic hepatitis?
``` Treat infection and encephalopathy Alcohol withdrawal Protect against GI bleeding Airway protection/ ITU care Review nutrition (frequent feeds) Thiamine ```
28
What is the presentation of spontaneous bacterial peritonitis?
``` Abdominal pain Fever, rigors Renal impairment Sepsis Tachycardia Temp? ```
29
What are the clinical signs of spontaneous bacterial peritonitis?
Neutrophil count >0.25x10(9)/L Protein <25g/L Ascitic tap (cultures, WCC, fluid protein and glucose levels)
30
What is the treatment for spontaneous bacterial peritonitis?
IV antibiotics Ascetic fluid drainage IV albumin infusion
31
What are the causes of hepatic encephalopathy?
Infection Drugs Constipation GI bleed
32
How do you treat hepatic encephalopathy?
Bowel clear out, lactulose, enemas | Antibiotics