Lipid Drugs

Question 1

Lipid lowering drugs

Answer 1

HMG CoA reductase inhibitor, resins, ezetimibe, niacin, fibrates

Question 2

Drugs most effective at lowering triglyceride and VLDL and raising HDL

Answer 2

Niacine, fibrates

Question 3

Reversible inhibitor of HMG CoA reductase

Answer 3

Statins (simvastatin etc)

Question 4

Binds bile acids, preventing reabsorptionb of bile acids and increasing cholesterol utilization for replacement

Answer 4

Cholestyramine

Question 5

Cholestyramine is CI in

Answer 5

Diverticulitis

Question 6

Selective inhibitor of the NPC1L1 transporter

Answer 6

Ezetimibe

Question 7

Most effective agent for raising HDL

Answer 7

Niacin

Question 8

Drugs that cause flushing

Answer 8

VANC(vancomycin, adenosine, niacin, calcium channel blockers)

Question 9

DOC for hypertriglyceridemia

Answer 9

Gemfibrozil

Question 10

Increased risk of myopathy and rhabdomyolysis

Answer 10

Statins & gemfibrozil

Question 11

Drugs most effective at lowering LDL

Answer 11

Statins, resins, ezetimibe, niacin

Question 12

Clear VLDL and LDL remnants from blood

Answer 12

High affinity LDL receptors

Question 13

Statins have an increased risk of rhabdomyolosis and myopathies when given with wc drug

Answer 13

Fibrates

Question 14

Anithyperlipidemic combination that may cause increased risk for cholelithiasis

Answer 14

Fibrate+ resin

Question 15

Anithyperlipidemic combination that may cause impaired statin absorption

Answer 15

Statin+ resin

Question 16

Inherited lipoprototeinemia with deficiency in LPL or ApoC II

Answer 16

Type 1 primary hyperchylomicronemia/ familial lipoprotein lipase deficiency

Question 17

Inherited lipoprototeinemia with deficiency/defect in LDL receptors

Answer 17

Familial hypercholesterolemia -II

Question 18

Inherited lipoprototeinemia with deficiency in ApoE

Answer 18

III- Familial dysbetalipoprotenemia

Question 19

Inherited lipoprototeinemia with decreased clearance or increased production of VLDL

Answer 19

IV- Familial hyperyriglyceridemia

Question 20

Xanthomas, pancreatitis, no increased risk of coronary heart disease

Answer 20

I- Primary hyperchylomicronemia

Question 21

Xanthomas, xanthelasmas with increased risk of atherosclerosis

Answer 21

II- Familial hypercholesterolemia

Question 22

Triad of cornary artery disease, DM type 2, obesity

Answer 22

Familial hypertriglycerdiemia

Question 23

Cholesterol analog, takes the place of dietary and biliary cholesterol, decreasing intestinal absorption of cholesterol and other phytosterols

Answer 23

Sitosterol

Question 24

Lipid lowering drug that also has an indication for digitalis toxicity

Answer 24

Cholestyramine

Question 25

Lipid lowering drug that may cause flushing

Answer 25

Niacin

Question 26

If given pretreatment may reduce flushing

Answer 26

Aspirin