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Pharmacology > Lipid Drugs > Flashcards

Lipid Drugs Flashcards

1
Q

Lipid lowering drugs

A

HMG CoA reductase inhibitor, resins, ezetimibe, niacin, fibrates

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2
Q

Drugs most effective at lowering triglyceride and VLDL and raising HDL

A

Niacine, fibrates

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3
Q

Reversible inhibitor of HMG CoA reductase

A

Statins (simvastatin etc)

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4
Q

Binds bile acids, preventing reabsorptionb of bile acids and increasing cholesterol utilization for replacement

A

Cholestyramine

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5
Q

Cholestyramine is CI in

A

Diverticulitis

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6
Q

Selective inhibitor of the NPC1L1 transporter

A

Ezetimibe

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7
Q

Most effective agent for raising HDL

A

Niacin

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8
Q

Drugs that cause flushing

A

VANC(vancomycin, adenosine, niacin, calcium channel blockers)

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9
Q

DOC for hypertriglyceridemia

A

Gemfibrozil

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10
Q

Increased risk of myopathy and rhabdomyolysis

A

Statins & gemfibrozil

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11
Q

Drugs most effective at lowering LDL

A

Statins, resins, ezetimibe, niacin

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12
Q

Clear VLDL and LDL remnants from blood

A

High affinity LDL receptors

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13
Q

Statins have an increased risk of rhabdomyolosis and myopathies when given with wc drug

A

Fibrates

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14
Q

Anithyperlipidemic combination that may cause increased risk for cholelithiasis

A

Fibrate+ resin

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15
Q

Anithyperlipidemic combination that may cause impaired statin absorption

A

Statin+ resin

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16
Q

Inherited lipoprototeinemia with deficiency in LPL or ApoC II

A

Type 1 primary hyperchylomicronemia/ familial lipoprotein lipase deficiency

17
Q

Inherited lipoprototeinemia with deficiency/defect in LDL receptors

A

Familial hypercholesterolemia -II

18
Q

Inherited lipoprototeinemia with deficiency in ApoE

A

III- Familial dysbetalipoprotenemia

19
Q

Inherited lipoprototeinemia with decreased clearance or increased production of VLDL

A

IV- Familial hyperyriglyceridemia

20
Q

Xanthomas, pancreatitis, no increased risk of coronary heart disease

A

I- Primary hyperchylomicronemia

21
Q

Xanthomas, xanthelasmas with increased risk of atherosclerosis

A

II- Familial hypercholesterolemia

22
Q

Triad of cornary artery disease, DM type 2, obesity

A

Familial hypertriglycerdiemia

23
Q

Cholesterol analog, takes the place of dietary and biliary cholesterol, decreasing intestinal absorption of cholesterol and other phytosterols

A

Sitosterol

24
Q

Lipid lowering drug that also has an indication for digitalis toxicity

A

Cholestyramine

25
Q

Lipid lowering drug that may cause flushing

A

Niacin

26
Q

If given pretreatment may reduce flushing

A

Aspirin

Pharmacology (38 decks)

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