Bacterial Protein Synthesis Inhibitors Flashcards
as the plasma level is increased above the MIC, an increasing proportion of bacteria are killed and at a more rapid rate
Concentration-Dependent Killing Action
efficacy is directly related to time above MIC
Time-Dependent Killing Action
efficacy independent of concentration once the MIC has been reached
Time-Dependent Killing Action
killing action continues when their plasma levels have declined below measurable levels
Post Antibiotic Effect
narrowest therapeutic window among aminoglycosides
Amikacin
blocks the formation of the initiation complex
Aminoglycosides
infections caused by aerobic gram-negative bacteria (E. coli, Enterobacter, Klebsiella, Proteus, Providencia, Pseudomonas, Serratia) Endocarditis, Ocular infections
Gentamicin
most vestibulotoxic and nephrotoxic aminoglycosides
Gentamicin and Tobramycin
nephrotoxicity (reversible), ototoxicity (irreversible), neuromuscular blockade
Gentamicin
Multi-Drug Resistant Tuberculosis (2nd line drug)
Amikacin
least resistance among aminoglycosides but with narrowest therapeutic window
Amikacin
Tuberculosis, Tularemia, Bubonic plague, Brucellosis
Streptomycin
Teratogen (congenital deafness)
Streptomycin
skin infections, Bowel preparation, Hepatic encephalopathy
Neomycin
Leishmaniasis
Paromomycin
