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Pharmacology > Drugs Used In Parkinsonism > Flashcards

Drugs Used In Parkinsonism Flashcards

0
Q

Parkinsonism is due to

A

Degeneration of dopaminergic neurons in substantia nigra

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1
Q

Parkinsonism is also known as

A

Paralysis agtans

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2
Q

Drug induced parkinsonism is due to

A

Typical antipsychotics, reserpine, MPTP(methylphenyltetrahydropyridine)

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3
Q

Alternating periods of improved mobility and akinesia

A

On-Off phenomena

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4
Q

deterioration of drug effect in betweem medication dosese

A

Wearing off phenomena

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5
Q

Wearing off effect due to

A

destrucion of nigrostriatial neurons

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6
Q

Primary drug for Parkison’s

A

Levodopa Carbidopa

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7
Q

Carbidopa inhibits peripheral metabolism via

A

Dopa carboxylase

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8
Q

Levodopa Carbidopa CI in

A

Psychosis

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9
Q

Bromocriptine is partial agonist of

A

D2 receptors in brain

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10
Q

Used for levodopa intolerance and hyperprolactinemia

A

Bromocriptine

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11
Q

May cause erythromelalgia

A

Bromocriptine

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12
Q

Partial agonist at D3 receptors

A

Pramipexole

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13
Q

SE: Compulsive gambling, overeating

A

Pramipexole

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14
Q

Also for restless leg syndrome

A

Pramipexole

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15
Q

Partial agonist at D3 receptors. Antagonizes 5HT and alpha adrenoreceptors

A

Apomorphine

16
Q

Used for Off Periods

A

Apomorphine

17
Q

Also for alcoholism, Opiate addiction, Erectile dysfunction and Alzheimer’s

A

Apomorphine

18
Q

When giving Apomorphine what premedication is given

A

Trimethobenzamide

19
Q

MAO type B inhibitor, leades to decreased degredation of dopamine; Increases response to dopamine

A

Selegiline

20
Q

Serotonin syndrome when used with SSRI

A

Selegiline

21
Q

COMT inhibitor, thus blocks L dopa metabolism

A

Entacapone

22
Q

For Wearing Off phenomena

A

Entacapone

23
Q

Potentiates dopaminergic action, Influences synhtesis release or reuptake of dopamine at Adenosine 2A receptors

A

Amantadine

24
Q

Blue red lacy pattern at extremities

A

Livedo reticularis

25
Q

Decrease excitatatory actions of cholinergic neurons on cells in the striatum by blocking muscarinic receptors

A

Benztropine

26
Q

For extrapyramidal sx caused by antipsychotics

A

Benztropine

27
Q

Drugs used in Parkinsonism

A

Bromocriptine, Pramipexole, Apomorphine, Selegiline, Entacapone, Amantadine, Benztropine

Pharmacology (38 decks)

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