leukemia Flashcards
a cancer of the myeloid line of
blood cells, characterized by the rapid growth of abnormal cells
that build up in the bone marrow and blood and interfere with
normal blood cells
AML
caused by a DNA mutation in
the stem cells in the bone marrow that produce red blood cells,
platelets and infection-fighting white blood cells.
AML
The mutation causes the stem cells to produce many more white
blood cells than are needed
AML
skin looking pale or “washed out”
tiredness. breathlessness. having a high temperature, and feeling hot or shivery (fever)
sweating a lot.
losing weight without trying.
frequent infections. unusual and frequent bleeding, such as bleeding gums or nosebleed
Symptoms of AML
Present in the leukemia cells of approximately 60 to 70 percent of cases of AML. Linear structure of varying length and width
Auer Rod
What is a definitive evidence of AML?
One or more blasts from auer rods
Too many blood stem cells become a type of white blood cell called granulocytes. These granulocytes are abnormal and do not become healthy white blood cells. They are also called leukemia cells. The leukemia cells can build up in the blood and bone marrow so there is less room for healthy white blood cells, red blood cells,
and platelets.
When this happens, infection, anemia, or easy bleeding may occur:This describes what?
CML
tiredness.
weight loss.
night sweats.
tenderness and swelling in the left side of the abdomen
feeling full after small meals.
pale skin and shortness of breath.
a high temperature.
bruising and bleeding easily
Symptoms of CML
What is CML caused by
a rearrangement
(translocation ) of genetic material between chromosome 9 and chromosome 22.
This translocation, written as t(9;22), fuses part of the ABL1 gene from
chromosome 9 with part of the BCR gene from chromosome 22,
creating an abnormal fusion gene called BCR-ABL1
a disease in which patients
have too many mature white blood cells
CML
a disease in which patients
have too many immature white blood cells in their bone marrow that
are not capable of maturing properly.
AML
CML vs AML
CML or chronic myelogenous leukemia is a disease in which patients have too many mature white blood cells.
AML or acute myelogenous leukemia is a disease in which patients have too many immature white blood cells in their bone marrow that are not capable of maturing properly
Most common pediatric leukemia. A cancer that starts from the early version of white blood cells
called lymphocytes in the bone marrow
ALL
What is ALL?
A cancer that starts from the early version of white blood cells
called lymphocytes in the bone marrow
Certain chromosome rearrangements.
Exposure to radiation, including x-rays before birth.
Past treatment with chemotherapy drugs.
Receiving a bone marrow transplant.
Toxins, such as benzene.
symptoms of ALL
