Lesson 8 Papovaviridae

Question 1

Papovaviridae – cause ____ and _______ in domestic animals

Answer 1

– papillomas and fibropapillomas

Question 2

Papovaviridae – ____________________ and ______________________ may occur in cattle ingesting bracken

Answer 2

malignant transformation of alimentary and urinary tract papillomas

Question 3

Papovaviridae – ________________ is aetiologically implicated in equine sarcoids

Answer 3

bovine papillomavirus 1

Question 4

PAPOVAVIRIDAE
 Pathogenesis:
 _______________ infect the basal cells of squamous epithelium, due to minute abrasions or virus entry at vulnerable sites such as junctions between different types of epithelia.
 Infected cells proliferate but differentiation is delayed. Viral gene expression is restricted during this stage
 After proliferative phase, cellular differentiation begins in the more superficial epithelial layers followed by full gene expression resulting to the production of viral capsids.
 New virions can be visualized by electron microscopy in the nuclei of differentiated keratinized cells.
 Release of virus occurs during desquamation of infected cells from the surface of lesions.

Answer 4

*Papillomaviruses
Basaha an iba

Question 5

Fibropapillomas in cattle; occurs mainly in the head and neck and occassionally on penis. Genotype 2 has been implicated in bladder neoplasia and enzootic haematuria. BPV 1 has been aetiologically implicated in equine sarcoids

Answer 5

GENUS:
Delta papillomavirus

 VIRUS: Bovine papillomavirus 1	

GENOTYPE:
1,2

Question 6

Papillomas and fibropapillomas
(rare)

Answer 6

Genus:
Delta papillomavirus

Virus:
Ovine papillomas

Genotype:
1,2

Question 7

Cutaneous papillomas with tendency to persist

Answer 7

Genus:
Xipapillomavirus

Virus:
Bovine papillomavirus 3

Genotype:
3

Question 8

Papillomas in the upper alimentary tract, malignant transformation may result from ingestion of bracken fern

Answer 8

G:
Xipapillomavirus
V:
Bovine papillomavirus 3
GT:
4

Question 9

Papillomas in the teats of cow, “frond” type

Answer 9

G:
Xipapillomavirus
V:
Bovine papillomavirus 3
GT:
6

Question 10

Papillomas on the teats of cow

Answer 10

G:
Xipapillomavirus
V:
Bovine papillomavirus 3
GT:
9,10

Question 11

Papillomas on the teats “rice grain type” and udder

Answer 11

G:
Epsilonpapillomavirus

V:
Bovine papillomavirus 5

GT:
5

Question 12

Papillomas on the teats and skin

Answer 12

G:
Epsilonpapillomavirus

V:
Bovine papillomavirus 5

GT:
8

Question 13

Papillomas on the teats and skin

Answer 13

Novel genus proposed

Bovine papillomavirus

7

Question 14

Papillomas in young horses; occurs mainly around lips and on nose

Answer 14

Zetapapillomavirus
Equine papillomavirus 1

Question 15

Irregularly-shaped papillomas in the oral cavity of young dogs

Answer 15

Lambdapapillomavirus

Canine oralpapillomavirus

Question 16

Uncommon, skin and oral cavity papillomas

Answer 16

Lambdapapillomavirus

Feline papillomavirus