Lesson 23: Arenaviridae

Question 1

General description:
 Virions are pleomorphic, enveloped, 50–300 (generally 110–130) nm in size
 Segmented. Genome consists of two segments, large (L, 7.2 kb) and small (S,
3.4 kb), of single-stranded RNA, both ambisense
 Viral proteins: nucleoprotein (N), RNA-dependent RNA polymerase (L), two
glycoproteins (Gp1, Gp2), zinc-binding protein (Z), plus minor proteins

Answer 1

Replication occurs in the cytoplasm; generally non-cytocidal; persistent infections
 Maturation occurs by budding from the plasma membrane
 Genetic reassortment occurs between closely related viruses

Question 2

Table 114