LEPTOSPIROSIS Flashcards
A rare bacterial infection that is spread through urine of rodents, and farm animals
LEPTOSPIROSIS
OTHER NAMES OF LEPTOSPIROSIS
M, T, W, F, S, J (Mon., tues., wed., fri., sat., Jesus (sunday))
M- mud fever
T- trench fever
W- weil’s dse.
F- flood fever
S- spiroketal jaundice
J- japanese seven days fever
LEPTOSPIROSIS Causative agent
Leptospira interrogans
LEPTOSPIROSIS Classification
Bacterial
LEPTOSPIROSIS Incubation period
7-19 days (mabilis magtravel and can damage liver)
LEPTOSPIROSIS Mode of transmission
Inoculation (penetrates wound)
LEPTOSPIROSIS Clinical manifestations
2 phases
- Anicteric/febrile phase
- Icteric/icterus phase
LEPTOSPIROSIS: Anicteric/febrile phase
- NO JAUNDICE
- fever, chills, headache, N/V, loss of appetite (anorexia), myalgia
LEPTOSPIROSIS: Icteric/icterus phase
- WITH JAUNDICE
- pruritic and dry skin, clay colored stool (pale stool- alcoholic)
LEPTOSPIROSIS Dx text
BACTERIAL CULTURE
(Identify the exact organism to administer proper antibiotic)
LEPTOSPIROSIS Treatment of choice (DOC)
- PEN. G: 2M units q 6h/IM/IV
- TETRACYCLINE:100 MG q12 PO (common side effect= permanent staining of teeth, it should be administered through straw)
LEPTOSPIROSIS PATHOGENESIS
- Bacteria will inoculate the body after penetrating exposed mucous membranes or an open wound
- Circulate in the blood and replicate
- Travel and colonize the spleen, liver, lungs, and kidneys
- Colonizes the renal tubules in the kidneys
- Promoting lymphocyte infiltration
- Hypokalemia, natriuresis, magnesium loss, and an abrupt decrease in creatinine clearance
- Disorganizes hepatocytes with disruption of intercellular junctions
- Moderate elevation of liver transaminases and direct bilirubin cholestasis
- Anicteric and icteric phase.
